PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription

Transcription complexes that assemble at the HIV-1 promoter efficiently initiate transcription but generate paused RNA polymerase II downstream from the start site. The virally encoded Tat protein hijacks positive transcription elongation factor b (P-TEFb) to phosphorylate and activate this paused p...

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Detalles Bibliográficos
Autores principales: Faust, Tyler B., Li, Yang, Jang, Gwendolyn M., Johnson, Jeffrey R., Yang, Shumin, Weiss, Amit, Krogan, Nevan J., Frankel, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366948/
https://www.ncbi.nlm.nih.gov/pubmed/28345603
http://dx.doi.org/10.1038/srep45394

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