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Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics
Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367017/ https://www.ncbi.nlm.nih.gov/pubmed/28257059 http://dx.doi.org/10.3390/md15030060 |
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author | Hong, Seong-Chul Yoo, Seung-Yup Kim, Hyeongmin Lee, Jaehwi |
author_facet | Hong, Seong-Chul Yoo, Seung-Yup Kim, Hyeongmin Lee, Jaehwi |
author_sort | Hong, Seong-Chul |
collection | PubMed |
description | Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives. |
format | Online Article Text |
id | pubmed-5367017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53670172017-03-31 Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics Hong, Seong-Chul Yoo, Seung-Yup Kim, Hyeongmin Lee, Jaehwi Mar Drugs Review Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives. MDPI 2017-03-01 /pmc/articles/PMC5367017/ /pubmed/28257059 http://dx.doi.org/10.3390/md15030060 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hong, Seong-Chul Yoo, Seung-Yup Kim, Hyeongmin Lee, Jaehwi Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title | Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title_full | Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title_fullStr | Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title_full_unstemmed | Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title_short | Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics |
title_sort | chitosan-based multifunctional platforms for local delivery of therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367017/ https://www.ncbi.nlm.nih.gov/pubmed/28257059 http://dx.doi.org/10.3390/md15030060 |
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