Phakellistatins: An Underwater Unsolved Puzzle

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1–19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, alo...

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Detalles Bibliográficos
Autores principales: Meli, Alessandra, Tedesco, Consiglia, Della Sala, Giorgio, Schettini, Rosaria, Albericio, Fernando, De Riccardis, Francesco, Izzo, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367035/
https://www.ncbi.nlm.nih.gov/pubmed/28335479
http://dx.doi.org/10.3390/md15030078
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author Meli, Alessandra
Tedesco, Consiglia
Della Sala, Giorgio
Schettini, Rosaria
Albericio, Fernando
De Riccardis, Francesco
Izzo, Irene
author_facet Meli, Alessandra
Tedesco, Consiglia
Della Sala, Giorgio
Schettini, Rosaria
Albericio, Fernando
De Riccardis, Francesco
Izzo, Irene
author_sort Meli, Alessandra
collection PubMed
description A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1–19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
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spelling pubmed-53670352017-03-31 Phakellistatins: An Underwater Unsolved Puzzle Meli, Alessandra Tedesco, Consiglia Della Sala, Giorgio Schettini, Rosaria Albericio, Fernando De Riccardis, Francesco Izzo, Irene Mar Drugs Review A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1–19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility. MDPI 2017-03-18 /pmc/articles/PMC5367035/ /pubmed/28335479 http://dx.doi.org/10.3390/md15030078 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meli, Alessandra
Tedesco, Consiglia
Della Sala, Giorgio
Schettini, Rosaria
Albericio, Fernando
De Riccardis, Francesco
Izzo, Irene
Phakellistatins: An Underwater Unsolved Puzzle
title Phakellistatins: An Underwater Unsolved Puzzle
title_full Phakellistatins: An Underwater Unsolved Puzzle
title_fullStr Phakellistatins: An Underwater Unsolved Puzzle
title_full_unstemmed Phakellistatins: An Underwater Unsolved Puzzle
title_short Phakellistatins: An Underwater Unsolved Puzzle
title_sort phakellistatins: an underwater unsolved puzzle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367035/
https://www.ncbi.nlm.nih.gov/pubmed/28335479
http://dx.doi.org/10.3390/md15030078
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