Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL

Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spect...

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Autores principales: Ding, Hui, Ding, Wanjing, Ma, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367041/
https://www.ncbi.nlm.nih.gov/pubmed/28327529
http://dx.doi.org/10.3390/md15030086
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author Ding, Hui
Ding, Wanjing
Ma, Zhongjun
author_facet Ding, Hui
Ding, Wanjing
Ma, Zhongjun
author_sort Ding, Hui
collection PubMed
description Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns. This is the first systematic report on the mass spectrometric characteristics of prenylated indole derivatives.
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spelling pubmed-53670412017-03-31 Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL Ding, Hui Ding, Wanjing Ma, Zhongjun Mar Drugs Article Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns. This is the first systematic report on the mass spectrometric characteristics of prenylated indole derivatives. MDPI 2017-03-22 /pmc/articles/PMC5367041/ /pubmed/28327529 http://dx.doi.org/10.3390/md15030086 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Hui
Ding, Wanjing
Ma, Zhongjun
Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title_full Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title_fullStr Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title_full_unstemmed Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title_short Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL
title_sort mass spectrometric characteristics of prenylated indole derivatives from marine-derived penicillium sp. nh-sl
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367041/
https://www.ncbi.nlm.nih.gov/pubmed/28327529
http://dx.doi.org/10.3390/md15030086
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AT mazhongjun massspectrometriccharacteristicsofprenylatedindolederivativesfrommarinederivedpenicilliumspnhsl

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