The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function

A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent...

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Detalles Bibliográficos
Autores principales: Hong, Ka Young, Lee, Seung Hwan, Gu, Sohyun, Kim, Eunah, An, Sihyeon, Kwon, Junyoung, Lee, Jong-Bong, Jang, Sung Key
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367257/
https://www.ncbi.nlm.nih.gov/pubmed/28095120
http://dx.doi.org/10.1080/15476286.2017.1280224

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