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IsomiR expression patterns in canonical and Dicer-independent microRNAs
Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3′addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367367/ https://www.ncbi.nlm.nih.gov/pubmed/28098889 http://dx.doi.org/10.3892/mmr.2017.6117 |
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author | Liang, Tingming Yu, Jiafeng Liu, Chang Guo, Li |
author_facet | Liang, Tingming Yu, Jiafeng Liu, Chang Guo, Li |
author_sort | Liang, Tingming |
collection | PubMed |
description | Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3′addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer-independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer-independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non-dominant miRNA locus indicates an expression distribution similar to that of the Dicer-independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases. |
format | Online Article Text |
id | pubmed-5367367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-53673672017-04-13 IsomiR expression patterns in canonical and Dicer-independent microRNAs Liang, Tingming Yu, Jiafeng Liu, Chang Guo, Li Mol Med Rep Articles Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3′addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer-independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer-independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non-dominant miRNA locus indicates an expression distribution similar to that of the Dicer-independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases. D.A. Spandidos 2017-03 2017-01-13 /pmc/articles/PMC5367367/ /pubmed/28098889 http://dx.doi.org/10.3892/mmr.2017.6117 Text en Copyright: © Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Liang, Tingming Yu, Jiafeng Liu, Chang Guo, Li IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title | IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title_full | IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title_fullStr | IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title_full_unstemmed | IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title_short | IsomiR expression patterns in canonical and Dicer-independent microRNAs |
title_sort | isomir expression patterns in canonical and dicer-independent micrornas |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367367/ https://www.ncbi.nlm.nih.gov/pubmed/28098889 http://dx.doi.org/10.3892/mmr.2017.6117 |
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