Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016

In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs m...

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Autores principales: Baranovich, Tatiana, Vongphrachanh, Phengta, Ketmayoon, Pakapak, Sisouk, Thongchanh, Chomlasack, Khampheng, Khanthamaly, Viengphone, Nguyen, Ha Thuy, Mishin, Vasiliy P., Marjuki, Henju, Barnes, John R., Garten, Rebecca J., Stevens, James, Wentworth, David E., Gubareva, Larisa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367415/
https://www.ncbi.nlm.nih.gov/pubmed/28322707
http://dx.doi.org/10.3201/eid2304.161876
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author Baranovich, Tatiana
Vongphrachanh, Phengta
Ketmayoon, Pakapak
Sisouk, Thongchanh
Chomlasack, Khampheng
Khanthamaly, Viengphone
Nguyen, Ha Thuy
Mishin, Vasiliy P.
Marjuki, Henju
Barnes, John R.
Garten, Rebecca J.
Stevens, James
Wentworth, David E.
Gubareva, Larisa V.
author_facet Baranovich, Tatiana
Vongphrachanh, Phengta
Ketmayoon, Pakapak
Sisouk, Thongchanh
Chomlasack, Khampheng
Khanthamaly, Viengphone
Nguyen, Ha Thuy
Mishin, Vasiliy P.
Marjuki, Henju
Barnes, John R.
Garten, Rebecca J.
Stevens, James
Wentworth, David E.
Gubareva, Larisa V.
author_sort Baranovich, Tatiana
collection PubMed
description In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
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spelling pubmed-53674152017-04-07 Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016 Baranovich, Tatiana Vongphrachanh, Phengta Ketmayoon, Pakapak Sisouk, Thongchanh Chomlasack, Khampheng Khanthamaly, Viengphone Nguyen, Ha Thuy Mishin, Vasiliy P. Marjuki, Henju Barnes, John R. Garten, Rebecca J. Stevens, James Wentworth, David E. Gubareva, Larisa V. Emerg Infect Dis Dispatch In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation. Centers for Disease Control and Prevention 2017-04 /pmc/articles/PMC5367415/ /pubmed/28322707 http://dx.doi.org/10.3201/eid2304.161876 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Baranovich, Tatiana
Vongphrachanh, Phengta
Ketmayoon, Pakapak
Sisouk, Thongchanh
Chomlasack, Khampheng
Khanthamaly, Viengphone
Nguyen, Ha Thuy
Mishin, Vasiliy P.
Marjuki, Henju
Barnes, John R.
Garten, Rebecca J.
Stevens, James
Wentworth, David E.
Gubareva, Larisa V.
Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title_full Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title_fullStr Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title_full_unstemmed Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title_short Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016
title_sort antiviral drug–resistant influenza b viruses carrying h134n substitution in neuraminidase, laos, february 2016
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367415/
https://www.ncbi.nlm.nih.gov/pubmed/28322707
http://dx.doi.org/10.3201/eid2304.161876
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