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Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent preg...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367499/ https://www.ncbi.nlm.nih.gov/pubmed/28157826 http://dx.doi.org/10.1097/LGT.0000000000000293 |
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author | Chevreau, Julien Mercuzot, Antonin Foulon, Arthur Attencourt, Chirstophe Sergent, Fabrice Lanta, Ségolène Gondry, Jean |
author_facet | Chevreau, Julien Mercuzot, Antonin Foulon, Arthur Attencourt, Chirstophe Sergent, Fabrice Lanta, Ségolène Gondry, Jean |
author_sort | Chevreau, Julien |
collection | PubMed |
description | OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA. RESULTS: Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%). CONCLUSIONS: Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL. |
format | Online Article Text |
id | pubmed-5367499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-53674992017-04-07 Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study Chevreau, Julien Mercuzot, Antonin Foulon, Arthur Attencourt, Chirstophe Sergent, Fabrice Lanta, Ségolène Gondry, Jean J Low Genit Tract Dis Original Research Articles: Cervix and HPV OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA. RESULTS: Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%). CONCLUSIONS: Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL. Lippincott Williams & Wilkins 2017-04 2017-02-03 /pmc/articles/PMC5367499/ /pubmed/28157826 http://dx.doi.org/10.1097/LGT.0000000000000293 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society for Colposcopy and Cervical Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Research Articles: Cervix and HPV Chevreau, Julien Mercuzot, Antonin Foulon, Arthur Attencourt, Chirstophe Sergent, Fabrice Lanta, Ségolène Gondry, Jean Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title | Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title_full | Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title_fullStr | Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title_full_unstemmed | Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title_short | Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study |
title_sort | impact of age at conization on obstetrical outcome: a case-control study |
topic | Original Research Articles: Cervix and HPV |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367499/ https://www.ncbi.nlm.nih.gov/pubmed/28157826 http://dx.doi.org/10.1097/LGT.0000000000000293 |
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