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Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study

OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent preg...

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Autores principales: Chevreau, Julien, Mercuzot, Antonin, Foulon, Arthur, Attencourt, Chirstophe, Sergent, Fabrice, Lanta, Ségolène, Gondry, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367499/
https://www.ncbi.nlm.nih.gov/pubmed/28157826
http://dx.doi.org/10.1097/LGT.0000000000000293
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author Chevreau, Julien
Mercuzot, Antonin
Foulon, Arthur
Attencourt, Chirstophe
Sergent, Fabrice
Lanta, Ségolène
Gondry, Jean
author_facet Chevreau, Julien
Mercuzot, Antonin
Foulon, Arthur
Attencourt, Chirstophe
Sergent, Fabrice
Lanta, Ségolène
Gondry, Jean
author_sort Chevreau, Julien
collection PubMed
description OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA. RESULTS: Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%). CONCLUSIONS: Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL.
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spelling pubmed-53674992017-04-07 Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study Chevreau, Julien Mercuzot, Antonin Foulon, Arthur Attencourt, Chirstophe Sergent, Fabrice Lanta, Ségolène Gondry, Jean J Low Genit Tract Dis Original Research Articles: Cervix and HPV OBJECTIVE: The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. MATERIALS AND METHODS: A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of LEEP (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA. RESULTS: Patients characteristics were comparable in terms of excised specimen thickness and pathological analysis, as well as for tobacco intoxication during pregnancy. Although there was no difference of term at delivery or total number of preterm adverse obstetrical events, we found a significant increase of events (19% vs 4.1%) and PL (19% vs 0%) before 26 WA in the group of patients younger than 25 years. After adjusting for excised specimen thickness, the same results were found for thickness of 15 mm or less (respectively, 16.7% vs 3.3% and 16.7% vs 0%). For thickness of greater than 15 mm, only ratio of PL before 26 WA was higher in the group of patients younger than 25 years (33.3% vs 0%). CONCLUSIONS: Age younger than 25 years at the time of LEEP seems to be is associated with a more frequent occurrence of extremely early preterm adverse obstetrical events, particularly PL. Lippincott Williams & Wilkins 2017-04 2017-02-03 /pmc/articles/PMC5367499/ /pubmed/28157826 http://dx.doi.org/10.1097/LGT.0000000000000293 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society for Colposcopy and Cervical Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Articles: Cervix and HPV
Chevreau, Julien
Mercuzot, Antonin
Foulon, Arthur
Attencourt, Chirstophe
Sergent, Fabrice
Lanta, Ségolène
Gondry, Jean
Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title_full Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title_fullStr Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title_full_unstemmed Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title_short Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
title_sort impact of age at conization on obstetrical outcome: a case-control study
topic Original Research Articles: Cervix and HPV
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367499/
https://www.ncbi.nlm.nih.gov/pubmed/28157826
http://dx.doi.org/10.1097/LGT.0000000000000293
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