The role of biomarkers in the diagnosis of periprosthetic joint infection

The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked. We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have bee...

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Autores principales: Shahi, AliSina, Parvizi, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2016
Materias:
General Orthopaedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367543/
https://www.ncbi.nlm.nih.gov/pubmed/28461959
http://dx.doi.org/10.1302/2058-5241.1.160019
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author Shahi, AliSina
Parvizi, Javad
author_facet Shahi, AliSina
Parvizi, Javad
author_sort Shahi, AliSina
collection PubMed
description The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked. We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have been introduced such as synovial fluid alpha defensin and leukocyte esterase. The synovial fluid leukocyte esterase test has a low cost, is accessible, and has provided promising results for diagnosing PJI. There is an urgent need for an accurate and reliable serum biomarker for diagnosing patients with PJI. Cite this article: Shahi A, Parvizi J. The role of biomarkers in the diagnosis of periprosthetic joint infection. EFORT Open Rev 2016;1:275-278. DOI: 10.1302/2058-5241.1.160019.
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spelling pubmed-53675432017-05-01 The role of biomarkers in the diagnosis of periprosthetic joint infection Shahi, AliSina Parvizi, Javad EFORT Open Rev General Orthopaedics The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked. We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have been introduced such as synovial fluid alpha defensin and leukocyte esterase. The synovial fluid leukocyte esterase test has a low cost, is accessible, and has provided promising results for diagnosing PJI. There is an urgent need for an accurate and reliable serum biomarker for diagnosing patients with PJI. Cite this article: Shahi A, Parvizi J. The role of biomarkers in the diagnosis of periprosthetic joint infection. EFORT Open Rev 2016;1:275-278. DOI: 10.1302/2058-5241.1.160019. British Editorial Society of Bone and Joint Surgery 2016-07-26 /pmc/articles/PMC5367543/ /pubmed/28461959 http://dx.doi.org/10.1302/2058-5241.1.160019 Text en © 2016 The author(s) https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
spellingShingle General Orthopaedics
Shahi, AliSina
Parvizi, Javad
The role of biomarkers in the diagnosis of periprosthetic joint infection
title The role of biomarkers in the diagnosis of periprosthetic joint infection
title_full The role of biomarkers in the diagnosis of periprosthetic joint infection
title_fullStr The role of biomarkers in the diagnosis of periprosthetic joint infection
title_full_unstemmed The role of biomarkers in the diagnosis of periprosthetic joint infection
title_short The role of biomarkers in the diagnosis of periprosthetic joint infection
title_sort role of biomarkers in the diagnosis of periprosthetic joint infection
topic General Orthopaedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367543/
https://www.ncbi.nlm.nih.gov/pubmed/28461959
http://dx.doi.org/10.1302/2058-5241.1.160019
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