Cargando…

Primary pancreatic lymphoma: two case reports and a literature review

Primary pancreatic lymphoma (PPL) is an extremely rare disease, with only a few cases reported in the literature. Clinical manifestations of PPL are often nonspecific and may mimic other pancreatic diseases. Because of the limited experience of PPL, clinicopathological features, differential diagnos...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Lili, Chen, Yajun, Xing, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367597/
https://www.ncbi.nlm.nih.gov/pubmed/28356755
http://dx.doi.org/10.2147/OTT.S121521
_version_ 1782517802489348096
author Yu, Lili
Chen, Yajun
Xing, Ligang
author_facet Yu, Lili
Chen, Yajun
Xing, Ligang
author_sort Yu, Lili
collection PubMed
description Primary pancreatic lymphoma (PPL) is an extremely rare disease, with only a few cases reported in the literature. Clinical manifestations of PPL are often nonspecific and may mimic other pancreatic diseases. Because of the limited experience of PPL, clinicopathological features, differential diagnosis, optimal therapy, and outcomes are not well defined. We described two cases diagnosed as PPL and confirmed by histological examination and immunohistochemical analysis. Case 1 was a young man with obstructive jaundice and upper abdominal malaise mimicking a pancreatic adenocarcinoma. A computed tomography (CT) scan revealed a diffuse heterogeneous mass in the head of the pancreas along with dilated bile ducts, no dilated pancreatic duct, no liver or splenic involvement, or evident retroperitoneal adenopathies. The patient underwent a pancreatico-duodenectomy, and the postoperative histopathology confirmed diffuse large B-cell non-Hodgkin lymphoma. Postoperatively, he received six courses of the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisolone). Case 2 was an older man with left flank pain. A CT confirmed a mass with irregular margins at the tail of the pancreas and the hilum of the spleen. The mass was heterogeneous, with no clear boundary between lesions, spleen, stomach, and pancreas, with nearby blood vessels wrapped around it, and multiple enlarged lymph nodes in the abdominal cavity. A CT-guided biopsy was performed. The immunohistological findings of the specimen revealed a diffuse large B-cell lymphoma. The size of the tumor was significantly reduced after four cycles of the CHOP chemotherapy regimen. These two cases were different in clinical manifestation, location, and treatment. We reviewed the literature and discussed the clinicopathological features, differential diagnosis, optimal therapy, and outcomes of this neoplasm.
format Online
Article
Text
id pubmed-5367597
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-53675972017-03-29 Primary pancreatic lymphoma: two case reports and a literature review Yu, Lili Chen, Yajun Xing, Ligang Onco Targets Ther Case Series Primary pancreatic lymphoma (PPL) is an extremely rare disease, with only a few cases reported in the literature. Clinical manifestations of PPL are often nonspecific and may mimic other pancreatic diseases. Because of the limited experience of PPL, clinicopathological features, differential diagnosis, optimal therapy, and outcomes are not well defined. We described two cases diagnosed as PPL and confirmed by histological examination and immunohistochemical analysis. Case 1 was a young man with obstructive jaundice and upper abdominal malaise mimicking a pancreatic adenocarcinoma. A computed tomography (CT) scan revealed a diffuse heterogeneous mass in the head of the pancreas along with dilated bile ducts, no dilated pancreatic duct, no liver or splenic involvement, or evident retroperitoneal adenopathies. The patient underwent a pancreatico-duodenectomy, and the postoperative histopathology confirmed diffuse large B-cell non-Hodgkin lymphoma. Postoperatively, he received six courses of the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisolone). Case 2 was an older man with left flank pain. A CT confirmed a mass with irregular margins at the tail of the pancreas and the hilum of the spleen. The mass was heterogeneous, with no clear boundary between lesions, spleen, stomach, and pancreas, with nearby blood vessels wrapped around it, and multiple enlarged lymph nodes in the abdominal cavity. A CT-guided biopsy was performed. The immunohistological findings of the specimen revealed a diffuse large B-cell lymphoma. The size of the tumor was significantly reduced after four cycles of the CHOP chemotherapy regimen. These two cases were different in clinical manifestation, location, and treatment. We reviewed the literature and discussed the clinicopathological features, differential diagnosis, optimal therapy, and outcomes of this neoplasm. Dove Medical Press 2017-03-20 /pmc/articles/PMC5367597/ /pubmed/28356755 http://dx.doi.org/10.2147/OTT.S121521 Text en © 2017 Yu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Yu, Lili
Chen, Yajun
Xing, Ligang
Primary pancreatic lymphoma: two case reports and a literature review
title Primary pancreatic lymphoma: two case reports and a literature review
title_full Primary pancreatic lymphoma: two case reports and a literature review
title_fullStr Primary pancreatic lymphoma: two case reports and a literature review
title_full_unstemmed Primary pancreatic lymphoma: two case reports and a literature review
title_short Primary pancreatic lymphoma: two case reports and a literature review
title_sort primary pancreatic lymphoma: two case reports and a literature review
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367597/
https://www.ncbi.nlm.nih.gov/pubmed/28356755
http://dx.doi.org/10.2147/OTT.S121521
work_keys_str_mv AT yulili primarypancreaticlymphomatwocasereportsandaliteraturereview
AT chenyajun primarypancreaticlymphomatwocasereportsandaliteraturereview
AT xingligang primarypancreaticlymphomatwocasereportsandaliteraturereview