Cargando…

Common and rare exonic MUC5B variants associated with type 2 diabetes in Han Chinese

Genome-wide association studies have identified over one hundred common genetic risk variants associated with type 2 diabetes (T2D). However, most of the heritability of T2D has not been accounted for. In this study, we investigated the contribution of rare and common variants to T2D susceptibility...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Guanjie, Zhang, Zhenjian, Adebamowo, Sally N., Liu, Guozheng, Adeyemo, Adebowale, Zhou, Yanxun, Doumatey, Ayo P., Wang, Chuntao, Zhou, Jie, Yan, Wenqiang, Shriner, Daniel, Tekola-Ayele, Fasil, Bentley, Amy R., Jiang, Congqing, Rotimi, Charles N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367689/ https://www.ncbi.nlm.nih.gov/pubmed/28346466 http://dx.doi.org/10.1371/journal.pone.0173784

Ejemplares similares

An Improved F(st) Estimator
por: Chen, Guanjie, et al.
Publicado: (2015)

Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry
por: Shriner, Daniel, et al.
Publicado: (2014)

Ancient Human Migration after Out-of-Africa
por: Shriner, Daniel, et al.
Publicado: (2016)

Genetic Ancestry of Hadza and Sandawe Peoples Reveals Ancient Population Structure in Africa
por: Shriner, Daniel, et al.
Publicado: (2018)

Phenotypic variance explained by local ancestry in admixed African Americans
por: Shriner, Daniel, et al.
Publicado: (2015)

FTO Genetic Variation and Association With Obesity in West Africans and African Americans
por: Adeyemo, Adebowale, et al.
Publicado: (2010)

Time-to-event modeling of hypertension reveals the nonexistence of true controls
por: Shriner, Daniel, et al.
Publicado: (2020)

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals
por: Chen, Guanjie, et al.
Publicado: (2021)

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes
por: Chen, Guanjie, et al.
Publicado: (2022)

Universal genome-wide association studies: Powerful joint ancestry and association testing
por: Shriner, Daniel, et al.
Publicado: (2023)

Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
por: Bentley, Amy Rebecca, et al.
Publicado: (2012)

Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations
por: Adebamowo, Sally N., et al.
Publicado: (2016)

Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans
por: Doumatey, Ayo P., et al.
Publicado: (2020)

Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans
por: Shriner, Daniel, et al.
Publicado: (2015)

Genome-wide association study for proliferative diabetic retinopathy in Africans
por: Liu, Chang, et al.
Publicado: (2019)

Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp)
por: Chen, Guanjie, et al.
Publicado: (2012)

Transferability and Fine-Mapping of Genome-Wide Associated Loci for Adult Height across Human Populations
por: Shriner, Daniel, et al.
Publicado: (2009)

Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans
por: Adeyemo, Adebowale A., et al.
Publicado: (2015)

Transferability and Fine Mapping of genome-wide associated loci for lipids in African Americans
por: Adeyemo, Adebowale, et al.
Publicado: (2012)

A genome-wide association study of serum uric acid in African Americans
por: Charles, Bashira A, et al.
Publicado: (2011)

APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans
por: Bentley, Amy R., et al.
Publicado: (2015)

Multiple Loci Associated with Renal Function in African Americans
por: Shriner, Daniel, et al.
Publicado: (2012)

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits
por: Meeks, Karlijn A. C., et al.
Publicado: (2021)

Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans
por: Meeks, Karlijn A. C., et al.
Publicado: (2022)

Mapping of disease-associated variants in admixed populations
por: Shriner, Daniel, et al.
Publicado: (2011)

Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: A proteomics study
por: Doumatey, Ayo Priscille, et al.
Publicado: (2016)

Development of admixture mapping panels for African Americans from commercial high-density SNP arrays
por: Chen, Guanjie, et al.
Publicado: (2010)

UGT1A1 is a major locus influencing bilirubin levels in African Americans
por: Chen, Guanjie, et al.
Publicado: (2012)

Type 2 diabetes complications and comorbidity in Sub-Saharan Africans
por: Ekoru, Kenneth, et al.
Publicado: (2019)

A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
por: Adeyemo, Adebowale, et al.
Publicado: (2009)

Correction: Prediction of HLA Class II Alleles Using SNPs in an African Population
por: Ayele, Fasil Tekola, et al.
Publicado: (2012)

Prediction of HLA Class II Alleles Using SNPs in an African Population
por: Ayele, Fasil Tekola, et al.
Publicado: (2012)

Clinical and Pharmacogenomic Implications of Genetic Variation in a Southern Ethiopian Population
por: Tekola-Ayele, Fasil, et al.
Publicado: (2014)

Gene-Based Sequencing Identifies Lipid-Influencing Variants with Ethnicity-Specific Effects in African Americans
por: Bentley, Amy R., et al.
Publicado: (2014)

Joint Ancestry and Association Testing in Admixed Individuals
por: Shriner, Daniel, et al.
Publicado: (2011)

Simple F Test Reveals Gene-Gene Interactions in Case-Control Studies
por: Chen, Guanjie, et al.
Publicado: (2012)

RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women
por: Famooto, Ayo, et al.
Publicado: (2013)

Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes
por: Meeks, Karlijn A. C., et al.
Publicado: (2023)

Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study
por: Tekola, Fasil, et al.
Publicado: (2009)

Genome science and health disparities: a growing success story?
por: Rotimi, Charles, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_316en7c8o25jecuom4fjcj09sq