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Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats
Cisplatin (cis-diaminedichloroplatinum II; CDDP) is an effective anticancer drug, but it has limitations because of its nephrotoxicity. This study investigates the protective effect of N-acetylcysteine (NAC) and taurine (TAU), both individually and in combination, against CDDP nephrotoxicity in rats...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367759/ https://www.ncbi.nlm.nih.gov/pubmed/28356716 http://dx.doi.org/10.2147/DDDT.S131316 |
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author | Abdel-Wahab, Wessam M Moussa, Farouzia I Saad, Najwa A |
author_facet | Abdel-Wahab, Wessam M Moussa, Farouzia I Saad, Najwa A |
author_sort | Abdel-Wahab, Wessam M |
collection | PubMed |
description | Cisplatin (cis-diaminedichloroplatinum II; CDDP) is an effective anticancer drug, but it has limitations because of its nephrotoxicity. This study investigates the protective effect of N-acetylcysteine (NAC) and taurine (TAU), both individually and in combination, against CDDP nephrotoxicity in rats. For this purpose, 48 male rats were assigned into eight groups (n=6) as follows: 1) control group, 2) NAC group, 3) TAU group, 4) NAC–TAU group, 5) CDDP group, 6) CDDP–NAC group, 7) CDDP–TAU group, and 8) CDDP–NAC–TAU group. Cisplatin was administered as a single intraperitoneal injection at a concentration of 6 mg/kg. Three days after CDDP administration, NAC (50 mg/kg) and/or TAU (50 mg/kg) were administered three times weekly for four consecutive weeks. Kidney function markers in serum, urinary glucose and protein, as well as oxidant and antioxidant parameters in renal tissue were assessed. Administration of CDDP significantly elevated urinary glucose and protein, as well as serum creatinine, urea, and uric acid. Moreover, CDDP enhanced lipid peroxidation and suppressed the major enzymatic antioxidants in the kidney tissue. Treatment with NAC or TAU protected against the alterations in the serum, urine, and renal tissue when used individually along with CDDP. Furthermore, a combined therapy of both was more effective in ameliorating CDDP-induced nephrotoxicity, which points out to their synergistic effect. |
format | Online Article Text |
id | pubmed-5367759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53677592017-03-29 Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats Abdel-Wahab, Wessam M Moussa, Farouzia I Saad, Najwa A Drug Des Devel Ther Original Research Cisplatin (cis-diaminedichloroplatinum II; CDDP) is an effective anticancer drug, but it has limitations because of its nephrotoxicity. This study investigates the protective effect of N-acetylcysteine (NAC) and taurine (TAU), both individually and in combination, against CDDP nephrotoxicity in rats. For this purpose, 48 male rats were assigned into eight groups (n=6) as follows: 1) control group, 2) NAC group, 3) TAU group, 4) NAC–TAU group, 5) CDDP group, 6) CDDP–NAC group, 7) CDDP–TAU group, and 8) CDDP–NAC–TAU group. Cisplatin was administered as a single intraperitoneal injection at a concentration of 6 mg/kg. Three days after CDDP administration, NAC (50 mg/kg) and/or TAU (50 mg/kg) were administered three times weekly for four consecutive weeks. Kidney function markers in serum, urinary glucose and protein, as well as oxidant and antioxidant parameters in renal tissue were assessed. Administration of CDDP significantly elevated urinary glucose and protein, as well as serum creatinine, urea, and uric acid. Moreover, CDDP enhanced lipid peroxidation and suppressed the major enzymatic antioxidants in the kidney tissue. Treatment with NAC or TAU protected against the alterations in the serum, urine, and renal tissue when used individually along with CDDP. Furthermore, a combined therapy of both was more effective in ameliorating CDDP-induced nephrotoxicity, which points out to their synergistic effect. Dove Medical Press 2017-03-20 /pmc/articles/PMC5367759/ /pubmed/28356716 http://dx.doi.org/10.2147/DDDT.S131316 Text en © 2017 Abdel-Wahab et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Abdel-Wahab, Wessam M Moussa, Farouzia I Saad, Najwa A Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title | Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title_full | Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title_fullStr | Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title_full_unstemmed | Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title_short | Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
title_sort | synergistic protective effect of n-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367759/ https://www.ncbi.nlm.nih.gov/pubmed/28356716 http://dx.doi.org/10.2147/DDDT.S131316 |
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