Cargando…

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells

Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus. This phytochemical has been previously reported to be drug-like with full compliance to Lipinski’s rule of five and good physicochemical properties when compared with 95% of orally available drugs. It h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Etti, Imaobong Christopher, Rasedee, Abdullah, Hashim, Najihah Mohd, Abdul, Ahmad Bustamam, Kadir, Arifah, Yeap, Swee Keong, Waziri, Peter, Malami, Ibrahim, Lim, Kian Lam, Etti, Christopher J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367776/ https://www.ncbi.nlm.nih.gov/pubmed/28356713 http://dx.doi.org/10.2147/DDDT.S124324

Ejemplares similares

Artonin E and Structural Analogs from Artocarpus Species Abrogates Estrogen Receptor Signaling in Breast Cancer
por: Etti, Imaobong, et al.
Publicado: (2016)

The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
por: Etti, Imaobong Christopher, et al.
Publicado: (2017)

Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells
por: Malami, Ibrahim, et al.
Publicado: (2017)

Correction: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells
por: Malami, Ibrahim, et al.
Publicado: (2017)

In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica
por: Malami, Ibrahim, et al.
Publicado: (2016)

Clausenidin induces caspase-dependent apoptosis in colon cancer
por: Waziri, Peter M., et al.
Publicado: (2016)

An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53
por: Malami, Ibrahim, et al.
Publicado: (2017)

Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells
por: Waziri, Peter M, et al.
Publicado: (2018)

Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)
por: Ashwaq, Al-Abboodi Shakir, et al.
Publicado: (2016)

Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells
por: Rahman, Mashitoh Abd, et al.
Publicado: (2016)

Ultrastructural Study on the Antibacterial Activity of Artonin E versus Streptomycin against Staphylococcus aureus Strains
por: Zajmi, Asdren, et al.
Publicado: (2015)

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways
por: Foo, Jhi Biau, et al.
Publicado: (2014)

Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells
por: Ali, Norlaily Mohd, et al.
Publicado: (2017)

Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line
por: Rahman, Heshu Sulaiman, et al.
Publicado: (2014)

Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells via the Wnt/β-Catenin Signaling Pathway
por: Fani, Somayeh, et al.
Publicado: (2016)

In vitro investigation of cytotoxic and antioxidative activities of Ardisia crispa against breast cancer cell lines, MCF-7 and MDA-MB-231
por: Nordin, Muhammad Luqman, et al.
Publicado: (2018)

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line
por: Yeap, SweeKeong, et al.
Publicado: (2015)

Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials
por: Rahman, Heshu Sulaiman, et al.
Publicado: (2014)

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line
por: Ali, Norlaily Mohd, et al.
Publicado: (2016)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
por: Rahman, Heshu Sulaiman, et al.
Publicado: (2013)

Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid
por: Ho, Wan Yong, et al.
Publicado: (2021)

Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis
por: Razak, Nursyamirah Abd, et al.
Publicado: (2019)

Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile
por: Tor, Yin Sim, et al.
Publicado: (2015)

Zerumbone Suppresses Angiogenesis in HepG2 Cells through Inhibition of Matrix Metalloproteinase-9, Vascular Endothelial Growth Factor, and Vascular Endothelial Growth Factor Receptor Expressions
por: Samad, Nozlena Abdul, et al.
Publicado: (2017)

Recombinant human Erythropoietin enhanced the cytotoxic effects of tamoxifen toward the spheroid MCF-7 breast cancer cells
por: Shujaa Edin, Hareth Y., et al.
Publicado: (2021)

Flavokawain A Induces Apoptosis in MCF-7 and MDA-MB231 and Inhibits the Metastatic Process In Vitro
por: Abu, Nadiah, et al.
Publicado: (2014)

Recombinant Human erythropoietin reduces viability of MCF-7 breast cancer cells from 3D culture without caspase activation
por: ShujaaEdin, Hareth Y., et al.
Publicado: (2021)

Study on the relationship between livin expression and osteosarcoma
por: Du, Meng, et al.
Publicado: (2018)

Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling
por: Soonnarong, Rapeepun, et al.
Publicado: (2022)

3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
por: Abu, Nadiah, et al.
Publicado: (2013)

Relationship between Sanitation Hygiene and Health Care with Healthy Family Security of the Family of Smokers at Berastagi Subdistrict
por: Nurmaini, Nurmaini, et al.
Publicado: (2019)

In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell
por: Chong, Hueh Zan, et al.
Publicado: (2012)

Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
por: Guo, Hua, et al.
Publicado: (2013)

Inhibition of livin overcomes radioresistance in nasopharyngeal carcinoma cells
por: Ma, Fei, et al.
Publicado: (2020)

Effects of Artonin E on Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LoVo and HCT116 Cells
por: Yangnok, Kanyaluck, et al.
Publicado: (2022)

Livin/BIRC7 expression as malignancy marker in adrenocortical tumors
por: Altieri, Barbara, et al.
Publicado: (2016)

Prognostic value of Livin in surgical specimen and biopsy in patients with osteosarcoma
por: Zhou, Jian, et al.
Publicado: (2020)

Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro
por: Abu, Nadiah, et al.
Publicado: (2016)

Gamma delta T cells in non-immune patients during primary schistosomal infection
por: Schwartz, Eli, et al.
Publicado: (2014)

5610357 REDUCTION IN BLOOD TRANSFUSION BURDEN FOLLOWING INITIATION OF VOXELOTOR OR CRIZANLIZUMAB: A CASE SERIES
por: Baruwa Etti, A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_acp93ekje5arel85kdr73g5cus