Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome

Inflammation is a risk factor for prostate cancer, but the mechanisms by which inflammation increases that risk are poorly understood. Here, we demonstrate that low expression of CD38 identifies a progenitor-like subset of luminal cells in the human prostate. CD38(lo) luminal cells are enriched in g...

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Detalles Bibliográficos
Autores principales: Liu, Xian, Grogan, Tristan R., Hieronymus, Haley, Hashimoto, Takao, Mottahedeh, Jack, Cheng, Donghui, Zhang, Lijun, Huang, Kevin, Stoyanova, Tanya, Park, Jung Wook, Shkhyan, Ruzanna O., Nowroozizadeh, Behdokht, Rettig, Matthew B., Sawyers, Charles L., Elashoff, David, Horvath, Steve, Huang, Jiaoti, Witte, Owen N., Goldstein, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367888/
https://www.ncbi.nlm.nih.gov/pubmed/27926864
http://dx.doi.org/10.1016/j.celrep.2016.11.010

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