A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice

BACKGROUND AND PURPOSE: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS‐derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the vasomotor function of re...

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Detalles Bibliográficos
Autores principales: Chuaiphichai, Surawee, Crabtree, Mark J, Mcneill, Eileen, Hale, Ashley B, Trelfa, Lucy, Channon, Keith M, Douglas, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368052/
https://www.ncbi.nlm.nih.gov/pubmed/28128438
http://dx.doi.org/10.1111/bph.13728

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