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Importance of Metabolic Adaptations in Francisella Pathogenesis

Francisella tularensis is a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although, Francisell...

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Autores principales: Ziveri, Jason, Barel, Monique, Charbit, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368251/
https://www.ncbi.nlm.nih.gov/pubmed/28401066
http://dx.doi.org/10.3389/fcimb.2017.00096
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author Ziveri, Jason
Barel, Monique
Charbit, Alain
author_facet Ziveri, Jason
Barel, Monique
Charbit, Alain
author_sort Ziveri, Jason
collection PubMed
description Francisella tularensis is a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although, Francisella possesses the capacity to infect numerous mammalian cell types, the macrophage constitutes the main intracellular niche, used for in vivo bacterial dissemination. To survive and multiply within infected macrophages, Francisella must imperatively escape from the phagosomal compartment. In the cytosol, the bacterium needs to control the host innate immune response and adapt its metabolism to this nutrient-restricted niche. Our laboratory has shown that intracellular Francisella mainly relied on host amino acid as major gluconeogenic substrates and provided evidence that the host metabolism was also modified upon Francisella infection. We will review here our current understanding of how Francisella copes with the available nutrient sources provided by the host cell during the course of infection.
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spelling pubmed-53682512017-04-11 Importance of Metabolic Adaptations in Francisella Pathogenesis Ziveri, Jason Barel, Monique Charbit, Alain Front Cell Infect Microbiol Microbiology Francisella tularensis is a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although, Francisella possesses the capacity to infect numerous mammalian cell types, the macrophage constitutes the main intracellular niche, used for in vivo bacterial dissemination. To survive and multiply within infected macrophages, Francisella must imperatively escape from the phagosomal compartment. In the cytosol, the bacterium needs to control the host innate immune response and adapt its metabolism to this nutrient-restricted niche. Our laboratory has shown that intracellular Francisella mainly relied on host amino acid as major gluconeogenic substrates and provided evidence that the host metabolism was also modified upon Francisella infection. We will review here our current understanding of how Francisella copes with the available nutrient sources provided by the host cell during the course of infection. Frontiers Media S.A. 2017-03-28 /pmc/articles/PMC5368251/ /pubmed/28401066 http://dx.doi.org/10.3389/fcimb.2017.00096 Text en Copyright © 2017 Ziveri, Barel and Charbit. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ziveri, Jason
Barel, Monique
Charbit, Alain
Importance of Metabolic Adaptations in Francisella Pathogenesis
title Importance of Metabolic Adaptations in Francisella Pathogenesis
title_full Importance of Metabolic Adaptations in Francisella Pathogenesis
title_fullStr Importance of Metabolic Adaptations in Francisella Pathogenesis
title_full_unstemmed Importance of Metabolic Adaptations in Francisella Pathogenesis
title_short Importance of Metabolic Adaptations in Francisella Pathogenesis
title_sort importance of metabolic adaptations in francisella pathogenesis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368251/
https://www.ncbi.nlm.nih.gov/pubmed/28401066
http://dx.doi.org/10.3389/fcimb.2017.00096
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