Cargando…

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

BACKGROUND AND OBJECTIVES: Hepatitis C and chronic kidney disease (CKD) are major global health problems and are highly prevalent in Pakistan. There is limited information on prevalence of hepatitis C in patients with CKD not yet on dialysis. The objective of this study was to determine the frequenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Shafi, Salman Tahir, Hassan, Muhammad Zaigham, Saleem, Mohammed, Anjum, Roshina, Abdullah, Wajid, Shafi, Tahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368304/
https://www.ncbi.nlm.nih.gov/pubmed/28367165
http://dx.doi.org/10.12669/pjms.331.11553
_version_ 1782517903324610560
author Shafi, Salman Tahir
Hassan, Muhammad Zaigham
Saleem, Mohammed
Anjum, Roshina
Abdullah, Wajid
Shafi, Tahir
author_facet Shafi, Salman Tahir
Hassan, Muhammad Zaigham
Saleem, Mohammed
Anjum, Roshina
Abdullah, Wajid
Shafi, Tahir
author_sort Shafi, Salman Tahir
collection PubMed
description BACKGROUND AND OBJECTIVES: Hepatitis C and chronic kidney disease (CKD) are major global health problems and are highly prevalent in Pakistan. There is limited information on prevalence of hepatitis C in patients with CKD not yet on dialysis. The objective of this study was to determine the frequency of hepatitis C in hospitalized chronic kidney disease patients at a tertiary care center in Pakistan. METHODS: The study design was cross-sectional in nature. Patients between ages of 20-80 years with CKD not previously on renal replacement therapy and who were admitted to nephrology ward at a tertiary care facility were included. Hepatitis C was tested using 3(rd) generation enzyme linked immunosorbent assay (ELISA). Hepatitis C RNA was tested by polymerase chain reaction (PCR) in patients with positive ELISA. RESULTS: A total of 180 patients were included in the study. Mean age of patients was 48.7±14.9 years. Of all patients, 105 (58.3%) were males and 75 (41.7%) were females, 152 (84.4%) had hypertension, 113 (62.8%) had diabetes mellitus and 26 (14.9%) had known cardiovascular disease. Mean eGFR of patients was 11.4±9.4 ml/min/1.73 m2. Of all patients with CKD, 49 (27.2%) had hepatitis C test positive by ELISA. Hepatitis C PCR testing was done in 39 patients with hepatitis C ELISA positive status and 29 (74.4%) tested positive. Risk factors and clinical characteristics of patients with and without positive hepatitis C antibody by ELISA were similar. CONCLUSION: A significant proportion of hospitalized CKD patients have hepatitis C. Strict universal infection control measures should be implemented in nephrology wards to prevent transmission of hepatitis C infection.
format Online
Article
Text
id pubmed-5368304
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Professional Medical Publications
record_format MEDLINE/PubMed
spelling pubmed-53683042017-03-31 Frequency of Hepatitis C in hospitalized patients with chronic kidney disease Shafi, Salman Tahir Hassan, Muhammad Zaigham Saleem, Mohammed Anjum, Roshina Abdullah, Wajid Shafi, Tahir Pak J Med Sci Original Article BACKGROUND AND OBJECTIVES: Hepatitis C and chronic kidney disease (CKD) are major global health problems and are highly prevalent in Pakistan. There is limited information on prevalence of hepatitis C in patients with CKD not yet on dialysis. The objective of this study was to determine the frequency of hepatitis C in hospitalized chronic kidney disease patients at a tertiary care center in Pakistan. METHODS: The study design was cross-sectional in nature. Patients between ages of 20-80 years with CKD not previously on renal replacement therapy and who were admitted to nephrology ward at a tertiary care facility were included. Hepatitis C was tested using 3(rd) generation enzyme linked immunosorbent assay (ELISA). Hepatitis C RNA was tested by polymerase chain reaction (PCR) in patients with positive ELISA. RESULTS: A total of 180 patients were included in the study. Mean age of patients was 48.7±14.9 years. Of all patients, 105 (58.3%) were males and 75 (41.7%) were females, 152 (84.4%) had hypertension, 113 (62.8%) had diabetes mellitus and 26 (14.9%) had known cardiovascular disease. Mean eGFR of patients was 11.4±9.4 ml/min/1.73 m2. Of all patients with CKD, 49 (27.2%) had hepatitis C test positive by ELISA. Hepatitis C PCR testing was done in 39 patients with hepatitis C ELISA positive status and 29 (74.4%) tested positive. Risk factors and clinical characteristics of patients with and without positive hepatitis C antibody by ELISA were similar. CONCLUSION: A significant proportion of hospitalized CKD patients have hepatitis C. Strict universal infection control measures should be implemented in nephrology wards to prevent transmission of hepatitis C infection. Professional Medical Publications 2017 /pmc/articles/PMC5368304/ /pubmed/28367165 http://dx.doi.org/10.12669/pjms.331.11553 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shafi, Salman Tahir
Hassan, Muhammad Zaigham
Saleem, Mohammed
Anjum, Roshina
Abdullah, Wajid
Shafi, Tahir
Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title_full Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title_fullStr Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title_full_unstemmed Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title_short Frequency of Hepatitis C in hospitalized patients with chronic kidney disease
title_sort frequency of hepatitis c in hospitalized patients with chronic kidney disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368304/
https://www.ncbi.nlm.nih.gov/pubmed/28367165
http://dx.doi.org/10.12669/pjms.331.11553
work_keys_str_mv AT shafisalmantahir frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease
AT hassanmuhammadzaigham frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease
AT saleemmohammed frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease
AT anjumroshina frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease
AT abdullahwajid frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease
AT shafitahir frequencyofhepatitiscinhospitalizedpatientswithchronickidneydisease