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Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy

Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided...

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Autores principales: Almosa, Ashwag A., Fawzy, Samah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368418/
https://www.ncbi.nlm.nih.gov/pubmed/28392938
http://dx.doi.org/10.1155/2017/2841408
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author Almosa, Ashwag A.
Fawzy, Samah M.
author_facet Almosa, Ashwag A.
Fawzy, Samah M.
author_sort Almosa, Ashwag A.
collection PubMed
description Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with/without MMC and myopic astigmatism with/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups. Results. One hundred fifty-nine eyes of 80 subjects (34 women and 46 men; mean age, 26.81 ± 7.74 years; range, 18–53 years; spherical powers, −0.50 to −8.00 DS; and cylindrical powers, −0.25 to −5.00 DC) were enrolled. One year postoperatively, the simple myopia with/without MMC groups showed no difference in UCVA (P = 0.187), BCVA (P = 0.163), or spherical equivalent (P = 0.163) and a significant difference (P = 0.0495) in K-reading; the haze formation difference was nonsignificant (P = 0.056). Astigmatic groups with/without MMC showed a significant difference in K-reading (P < 0.0001). MMC groups had less haze formation (P < 0.0001). Conclusion. PRK with intraoperative MMC application showed excellent visual outcomes. MMC's effect on astigmatic patients was significantly better with acceptable safety and minimal side effects.
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spelling pubmed-53684182017-04-09 Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy Almosa, Ashwag A. Fawzy, Samah M. J Ophthalmol Research Article Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with/without MMC and myopic astigmatism with/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups. Results. One hundred fifty-nine eyes of 80 subjects (34 women and 46 men; mean age, 26.81 ± 7.74 years; range, 18–53 years; spherical powers, −0.50 to −8.00 DS; and cylindrical powers, −0.25 to −5.00 DC) were enrolled. One year postoperatively, the simple myopia with/without MMC groups showed no difference in UCVA (P = 0.187), BCVA (P = 0.163), or spherical equivalent (P = 0.163) and a significant difference (P = 0.0495) in K-reading; the haze formation difference was nonsignificant (P = 0.056). Astigmatic groups with/without MMC showed a significant difference in K-reading (P < 0.0001). MMC groups had less haze formation (P < 0.0001). Conclusion. PRK with intraoperative MMC application showed excellent visual outcomes. MMC's effect on astigmatic patients was significantly better with acceptable safety and minimal side effects. Hindawi 2017 2017-03-14 /pmc/articles/PMC5368418/ /pubmed/28392938 http://dx.doi.org/10.1155/2017/2841408 Text en Copyright © 2017 Ashwag A. Almosa and Samah M. Fawzy. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Almosa, Ashwag A.
Fawzy, Samah M.
Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title_full Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title_fullStr Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title_full_unstemmed Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title_short Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy
title_sort effect of mitomycin c on myopic versus astigmatic photorefractive keratectomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368418/
https://www.ncbi.nlm.nih.gov/pubmed/28392938
http://dx.doi.org/10.1155/2017/2841408
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