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A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer
To make an optimal treatment decision for early stage breast cancer, it is important to identify risk of recurrence. Here, we developed and validated a new prognostic model for predicting the risk of distant metastasis in patients with pN0-N1, hormone receptor-positive, HER2-negative (HR+/HER2−) bre...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368569/ https://www.ncbi.nlm.nih.gov/pubmed/28350001 http://dx.doi.org/10.1038/srep45554 |
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author | Gong, Gyungyub Kwon, Mi Jeong Han, Jinil Lee, Hee Jin Lee, Se Kyung Lee, Jeong Eon Lee, Seon-Heui Park, Sarah Choi, Jong-Sun Cho, Soo Youn Ahn, Sei Hyun Lee, Jong Won Cho, Sang Rae Moon, Youngho Nam, Byung-Ho Nam, Seok Jin Choi, Yoon-La Shin, Young Kee |
author_facet | Gong, Gyungyub Kwon, Mi Jeong Han, Jinil Lee, Hee Jin Lee, Se Kyung Lee, Jeong Eon Lee, Seon-Heui Park, Sarah Choi, Jong-Sun Cho, Soo Youn Ahn, Sei Hyun Lee, Jong Won Cho, Sang Rae Moon, Youngho Nam, Byung-Ho Nam, Seok Jin Choi, Yoon-La Shin, Young Kee |
author_sort | Gong, Gyungyub |
collection | PubMed |
description | To make an optimal treatment decision for early stage breast cancer, it is important to identify risk of recurrence. Here, we developed and validated a new prognostic model for predicting the risk of distant metastasis in patients with pN0-N1, hormone receptor-positive, HER2-negative (HR+/HER2−) breast cancer treated with hormone therapy alone. RNA was extracted from formalin-fixed, paraffin-embedded tumor tissues and gene expression was measured by quantitative real-time reverse transcription-PCR. The relative expression of six novel prognostic genes was combined with two clinical variables (nodal status and tumor size) to calculate a risk score (BCT score). In the validation cohort treated with hormone therapy alone, the 10 year rate of distant metastasis in the high-risk group (26.3%) according to BCT score was significantly higher than that in the low-risk group (3.8%) (P < 0.001). Multivariate analysis adjusted for clinical variables revealed that BCT score is an independent predictor of distant metastasis. Moreover, the C-index estimate revealed that BCT score has a prognostic power superior to that of prognostic models based on clinicopathological parameters. The BCT score outperforms prognostic models based on traditional clinicopathological factors and predicts the risk of distant metastasis in patients with HR+/HER2− early breast cancer. |
format | Online Article Text |
id | pubmed-5368569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53685692017-03-30 A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer Gong, Gyungyub Kwon, Mi Jeong Han, Jinil Lee, Hee Jin Lee, Se Kyung Lee, Jeong Eon Lee, Seon-Heui Park, Sarah Choi, Jong-Sun Cho, Soo Youn Ahn, Sei Hyun Lee, Jong Won Cho, Sang Rae Moon, Youngho Nam, Byung-Ho Nam, Seok Jin Choi, Yoon-La Shin, Young Kee Sci Rep Article To make an optimal treatment decision for early stage breast cancer, it is important to identify risk of recurrence. Here, we developed and validated a new prognostic model for predicting the risk of distant metastasis in patients with pN0-N1, hormone receptor-positive, HER2-negative (HR+/HER2−) breast cancer treated with hormone therapy alone. RNA was extracted from formalin-fixed, paraffin-embedded tumor tissues and gene expression was measured by quantitative real-time reverse transcription-PCR. The relative expression of six novel prognostic genes was combined with two clinical variables (nodal status and tumor size) to calculate a risk score (BCT score). In the validation cohort treated with hormone therapy alone, the 10 year rate of distant metastasis in the high-risk group (26.3%) according to BCT score was significantly higher than that in the low-risk group (3.8%) (P < 0.001). Multivariate analysis adjusted for clinical variables revealed that BCT score is an independent predictor of distant metastasis. Moreover, the C-index estimate revealed that BCT score has a prognostic power superior to that of prognostic models based on clinicopathological parameters. The BCT score outperforms prognostic models based on traditional clinicopathological factors and predicts the risk of distant metastasis in patients with HR+/HER2− early breast cancer. Nature Publishing Group 2017-03-28 /pmc/articles/PMC5368569/ /pubmed/28350001 http://dx.doi.org/10.1038/srep45554 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Gong, Gyungyub Kwon, Mi Jeong Han, Jinil Lee, Hee Jin Lee, Se Kyung Lee, Jeong Eon Lee, Seon-Heui Park, Sarah Choi, Jong-Sun Cho, Soo Youn Ahn, Sei Hyun Lee, Jong Won Cho, Sang Rae Moon, Youngho Nam, Byung-Ho Nam, Seok Jin Choi, Yoon-La Shin, Young Kee A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title_full | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title_fullStr | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title_full_unstemmed | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title_short | A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer |
title_sort | new molecular prognostic score for predicting the risk of distant metastasis in patients with hr+/her2− early breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368569/ https://www.ncbi.nlm.nih.gov/pubmed/28350001 http://dx.doi.org/10.1038/srep45554 |
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