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Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection

AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and th...

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Autores principales: Chen, Mitchell, Mattar, Gaith, Abdulkarim, Jamal A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368630/
https://www.ncbi.nlm.nih.gov/pubmed/28396728
http://dx.doi.org/10.4329/wjr.v9.i3.143
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author Chen, Mitchell
Mattar, Gaith
Abdulkarim, Jamal A
author_facet Chen, Mitchell
Mattar, Gaith
Abdulkarim, Jamal A
author_sort Chen, Mitchell
collection PubMed
description AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units (HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans. RESULTS: Mean opacification was found to be positively correlated to patient age (Pearson’s correlation 0.4255, P < 0.0001) and independent of gender (male:female, 425.6 vs 450.4, P = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main (436.8 vs 437.9, P = 0.48), left (416.6 vs 419.8, P = 0.45) or the right pulmonary arteries (417.3 vs 423.5, P = 0.40). The number of sub-optimally opacified scans (the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups (7 vs 10). CONCLUSION: A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans.
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spelling pubmed-53686302017-04-10 Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection Chen, Mitchell Mattar, Gaith Abdulkarim, Jamal A World J Radiol Observational Study AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units (HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans. RESULTS: Mean opacification was found to be positively correlated to patient age (Pearson’s correlation 0.4255, P < 0.0001) and independent of gender (male:female, 425.6 vs 450.4, P = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main (436.8 vs 437.9, P = 0.48), left (416.6 vs 419.8, P = 0.45) or the right pulmonary arteries (417.3 vs 423.5, P = 0.40). The number of sub-optimally opacified scans (the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups (7 vs 10). CONCLUSION: A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans. Baishideng Publishing Group Inc 2017-03-28 2017-03-28 /pmc/articles/PMC5368630/ /pubmed/28396728 http://dx.doi.org/10.4329/wjr.v9.i3.143 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Chen, Mitchell
Mattar, Gaith
Abdulkarim, Jamal A
Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title_full Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title_fullStr Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title_full_unstemmed Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title_short Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
title_sort computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368630/
https://www.ncbi.nlm.nih.gov/pubmed/28396728
http://dx.doi.org/10.4329/wjr.v9.i3.143
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