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Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection
AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368630/ https://www.ncbi.nlm.nih.gov/pubmed/28396728 http://dx.doi.org/10.4329/wjr.v9.i3.143 |
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author | Chen, Mitchell Mattar, Gaith Abdulkarim, Jamal A |
author_facet | Chen, Mitchell Mattar, Gaith Abdulkarim, Jamal A |
author_sort | Chen, Mitchell |
collection | PubMed |
description | AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units (HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans. RESULTS: Mean opacification was found to be positively correlated to patient age (Pearson’s correlation 0.4255, P < 0.0001) and independent of gender (male:female, 425.6 vs 450.4, P = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main (436.8 vs 437.9, P = 0.48), left (416.6 vs 419.8, P = 0.45) or the right pulmonary arteries (417.3 vs 423.5, P = 0.40). The number of sub-optimally opacified scans (the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups (7 vs 10). CONCLUSION: A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans. |
format | Online Article Text |
id | pubmed-5368630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-53686302017-04-10 Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection Chen, Mitchell Mattar, Gaith Abdulkarim, Jamal A World J Radiol Observational Study AIM: To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA). METHODS: One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units (HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans. RESULTS: Mean opacification was found to be positively correlated to patient age (Pearson’s correlation 0.4255, P < 0.0001) and independent of gender (male:female, 425.6 vs 450.4, P = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main (436.8 vs 437.9, P = 0.48), left (416.6 vs 419.8, P = 0.45) or the right pulmonary arteries (417.3 vs 423.5, P = 0.40). The number of sub-optimally opacified scans (the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups (7 vs 10). CONCLUSION: A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans. Baishideng Publishing Group Inc 2017-03-28 2017-03-28 /pmc/articles/PMC5368630/ /pubmed/28396728 http://dx.doi.org/10.4329/wjr.v9.i3.143 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Observational Study Chen, Mitchell Mattar, Gaith Abdulkarim, Jamal A Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title_full | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title_fullStr | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title_full_unstemmed | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title_short | Computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
title_sort | computed tomography pulmonary angiography using a 20% reduction in contrast medium dose delivered in a multiphasic injection |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368630/ https://www.ncbi.nlm.nih.gov/pubmed/28396728 http://dx.doi.org/10.4329/wjr.v9.i3.143 |
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