Conditional Deletion of the Phd2 Gene in Articular Chondrocytes Accelerates Differentiation and Reduces Articular Cartilage Thickness

Based on our findings that PHD2 is a negative regulator of chondrocyte differentiation and that hypoxia signaling is implicated in the pathogenesis of osteoarthritis, we investigated the consequence of disruption of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice. Immunohi...

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Detalles Bibliográficos
Autores principales: Cheng, Shaohong, Pourteymoor, Sheila, Alarcon, Catrina, Mohan, Subburaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368651/
https://www.ncbi.nlm.nih.gov/pubmed/28349987
http://dx.doi.org/10.1038/srep45408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368651/
https://www.ncbi.nlm.nih.gov/pubmed/28349987
http://dx.doi.org/10.1038/srep45408

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