Epigenetics in Stroke Recovery

Abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be ta...

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Detalles Bibliográficos
Autores principales: Kassis, Haifa, Shehadah, Amjad, Chopp, Michael, Zhang, Zheng Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368693/
https://www.ncbi.nlm.nih.gov/pubmed/28264471
http://dx.doi.org/10.3390/genes8030089
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author Kassis, Haifa
Shehadah, Amjad
Chopp, Michael
Zhang, Zheng Gang
author_facet Kassis, Haifa
Shehadah, Amjad
Chopp, Michael
Zhang, Zheng Gang
author_sort Kassis, Haifa
collection PubMed
description Abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.
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spelling pubmed-53686932017-04-05 Epigenetics in Stroke Recovery Kassis, Haifa Shehadah, Amjad Chopp, Michael Zhang, Zheng Gang Genes (Basel) Review Abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery. MDPI 2017-02-27 /pmc/articles/PMC5368693/ /pubmed/28264471 http://dx.doi.org/10.3390/genes8030089 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kassis, Haifa
Shehadah, Amjad
Chopp, Michael
Zhang, Zheng Gang
Epigenetics in Stroke Recovery
title Epigenetics in Stroke Recovery
title_full Epigenetics in Stroke Recovery
title_fullStr Epigenetics in Stroke Recovery
title_full_unstemmed Epigenetics in Stroke Recovery
title_short Epigenetics in Stroke Recovery
title_sort epigenetics in stroke recovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368693/
https://www.ncbi.nlm.nih.gov/pubmed/28264471
http://dx.doi.org/10.3390/genes8030089
work_keys_str_mv AT kassishaifa epigeneticsinstrokerecovery
AT shehadahamjad epigeneticsinstrokerecovery
AT choppmichael epigeneticsinstrokerecovery
AT zhangzhenggang epigeneticsinstrokerecovery

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