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Efficacy of mistletoe for chemical pleurodesis in rats without malignancy

Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected...

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Autores principales: Ahn, Hyo Yeong, Cho, Jeong Su, Kim, Yeong Dae, I, Hoseok, Kim, Yeon Ji, Kim, Ahrong, Lee, Chang Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368846/
https://www.ncbi.nlm.nih.gov/pubmed/28352717
http://dx.doi.org/10.1515/med-2015-0051
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author Ahn, Hyo Yeong
Cho, Jeong Su
Kim, Yeong Dae
I, Hoseok
Kim, Yeon Ji
Kim, Ahrong
Lee, Chang Hun
author_facet Ahn, Hyo Yeong
Cho, Jeong Su
Kim, Yeong Dae
I, Hoseok
Kim, Yeon Ji
Kim, Ahrong
Lee, Chang Hun
author_sort Ahn, Hyo Yeong
collection PubMed
description Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME.
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spelling pubmed-53688462017-03-28 Efficacy of mistletoe for chemical pleurodesis in rats without malignancy Ahn, Hyo Yeong Cho, Jeong Su Kim, Yeong Dae I, Hoseok Kim, Yeon Ji Kim, Ahrong Lee, Chang Hun Open Med (Wars) Research Article Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME. De Gruyter Open 2015-09-04 /pmc/articles/PMC5368846/ /pubmed/28352717 http://dx.doi.org/10.1515/med-2015-0051 Text en © 2015 Hyo Yeong Ahn et al http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
spellingShingle Research Article
Ahn, Hyo Yeong
Cho, Jeong Su
Kim, Yeong Dae
I, Hoseok
Kim, Yeon Ji
Kim, Ahrong
Lee, Chang Hun
Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title_full Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title_fullStr Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title_full_unstemmed Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title_short Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
title_sort efficacy of mistletoe for chemical pleurodesis in rats without malignancy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368846/
https://www.ncbi.nlm.nih.gov/pubmed/28352717
http://dx.doi.org/10.1515/med-2015-0051
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