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Efficacy of mistletoe for chemical pleurodesis in rats without malignancy
Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter Open
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368846/ https://www.ncbi.nlm.nih.gov/pubmed/28352717 http://dx.doi.org/10.1515/med-2015-0051 |
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author | Ahn, Hyo Yeong Cho, Jeong Su Kim, Yeong Dae I, Hoseok Kim, Yeon Ji Kim, Ahrong Lee, Chang Hun |
author_facet | Ahn, Hyo Yeong Cho, Jeong Su Kim, Yeong Dae I, Hoseok Kim, Yeon Ji Kim, Ahrong Lee, Chang Hun |
author_sort | Ahn, Hyo Yeong |
collection | PubMed |
description | Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME. |
format | Online Article Text |
id | pubmed-5368846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | De Gruyter Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-53688462017-03-28 Efficacy of mistletoe for chemical pleurodesis in rats without malignancy Ahn, Hyo Yeong Cho, Jeong Su Kim, Yeong Dae I, Hoseok Kim, Yeon Ji Kim, Ahrong Lee, Chang Hun Open Med (Wars) Research Article Chemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague-Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME. De Gruyter Open 2015-09-04 /pmc/articles/PMC5368846/ /pubmed/28352717 http://dx.doi.org/10.1515/med-2015-0051 Text en © 2015 Hyo Yeong Ahn et al http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. |
spellingShingle | Research Article Ahn, Hyo Yeong Cho, Jeong Su Kim, Yeong Dae I, Hoseok Kim, Yeon Ji Kim, Ahrong Lee, Chang Hun Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title | Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title_full | Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title_fullStr | Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title_full_unstemmed | Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title_short | Efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
title_sort | efficacy of mistletoe for chemical pleurodesis in rats without malignancy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368846/ https://www.ncbi.nlm.nih.gov/pubmed/28352717 http://dx.doi.org/10.1515/med-2015-0051 |
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