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Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up

Malignant Hepatic Epithelioid hemangioendothelioma (HEHE) is an uncommon vascular tumor of intermediate malignant potential. HEHE is a rare tumor and it is difficult to diagnose for surgeons, hepatologists, radiologists and pathologists. So, misdiagnosis with a delay of the treatment is not uncommon...

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Autores principales: Giuliani, Antonio, Amato, Bruno, Marsilia, Giuseppina Marino, Tafuri, Domenico, Ceriello, Antonio, Santaniello, Walter, Sodano, Loredana, Rocca, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368874/
https://www.ncbi.nlm.nih.gov/pubmed/28352745
http://dx.doi.org/10.1515/med-2015-0086
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author Giuliani, Antonio
Amato, Bruno
Marsilia, Giuseppina Marino
Tafuri, Domenico
Ceriello, Antonio
Santaniello, Walter
Sodano, Loredana
Rocca, Aldo
author_facet Giuliani, Antonio
Amato, Bruno
Marsilia, Giuseppina Marino
Tafuri, Domenico
Ceriello, Antonio
Santaniello, Walter
Sodano, Loredana
Rocca, Aldo
author_sort Giuliani, Antonio
collection PubMed
description Malignant Hepatic Epithelioid hemangioendothelioma (HEHE) is an uncommon vascular tumor of intermediate malignant potential. HEHE is a rare tumor and it is difficult to diagnose for surgeons, hepatologists, radiologists and pathologists. So, misdiagnosis with a delay of the treatment is not uncommon. We describe a case of a young woman with a diagnosis of HEHE made 6 years after the first evidence of liver mass with a very long term follow-up after surgical treatment. She had two diagnoses of Hepatocellurar carcinoma (HCC) and a diagnosis of Cholangiocarcinoma after three different fine needle biopsies. After clinical observation, a new laparoscopic core biopsy was performed. In a first time approach, considering clinical and radiological patterns, a diagnosis of Budd-Chiari Syndrome was finally made. For that the patient underwent an orthotopicliver transplantation (OLTx). The surgical sample histological analysis allowed a definitive diagnosis of HEHE. At last, at follow up 7 years after three OLTx the patient is still alive and in good health with no evidence of recurrence.
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spelling pubmed-53688742017-03-28 Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up Giuliani, Antonio Amato, Bruno Marsilia, Giuseppina Marino Tafuri, Domenico Ceriello, Antonio Santaniello, Walter Sodano, Loredana Rocca, Aldo Open Med (Wars) Research Article Malignant Hepatic Epithelioid hemangioendothelioma (HEHE) is an uncommon vascular tumor of intermediate malignant potential. HEHE is a rare tumor and it is difficult to diagnose for surgeons, hepatologists, radiologists and pathologists. So, misdiagnosis with a delay of the treatment is not uncommon. We describe a case of a young woman with a diagnosis of HEHE made 6 years after the first evidence of liver mass with a very long term follow-up after surgical treatment. She had two diagnoses of Hepatocellurar carcinoma (HCC) and a diagnosis of Cholangiocarcinoma after three different fine needle biopsies. After clinical observation, a new laparoscopic core biopsy was performed. In a first time approach, considering clinical and radiological patterns, a diagnosis of Budd-Chiari Syndrome was finally made. For that the patient underwent an orthotopicliver transplantation (OLTx). The surgical sample histological analysis allowed a definitive diagnosis of HEHE. At last, at follow up 7 years after three OLTx the patient is still alive and in good health with no evidence of recurrence. De Gruyter Open 2015-12-21 /pmc/articles/PMC5368874/ /pubmed/28352745 http://dx.doi.org/10.1515/med-2015-0086 Text en © 2015 Antonio Giuliani et al http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
spellingShingle Research Article
Giuliani, Antonio
Amato, Bruno
Marsilia, Giuseppina Marino
Tafuri, Domenico
Ceriello, Antonio
Santaniello, Walter
Sodano, Loredana
Rocca, Aldo
Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title_full Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title_fullStr Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title_full_unstemmed Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title_short Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
title_sort our experience of liver epithelioid hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368874/
https://www.ncbi.nlm.nih.gov/pubmed/28352745
http://dx.doi.org/10.1515/med-2015-0086
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