New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

BACKGROUND: Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of infected erythrocytes, resulting in immune evasion and severe malaria disease. Sequencing and assembling the 40–60 var gene comp...

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Detalles Bibliográficos
Autores principales: Dara, Antoine, Drábek, Elliott F., Travassos, Mark A., Moser, Kara A., Delcher, Arthur L., Su, Qi, Hostelley, Timothy, Coulibaly, Drissa, Daou, Modibo, Dembele, Ahmadou, Diarra, Issa, Kone, Abdoulaye K., Kouriba, Bourema, Laurens, Matthew B., Niangaly, Amadou, Traore, Karim, Tolo, Youssouf, Fraser, Claire M., Thera, Mahamadou A., Djimde, Abdoulaye A., Doumbo, Ogobara K., Plowe, Christopher V., Silva, Joana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368897/
https://www.ncbi.nlm.nih.gov/pubmed/28351419
http://dx.doi.org/10.1186/s13073-017-0422-4

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