Cargando…
Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study
Long-term morbidities can develop after traumatic brain injury (TBI). Some studies have suggested that the risk of stroke is higher after TBI, but the association between concussion and stroke remains unclear. Using a national cohort, the authors analyzed the incidence of both hemorrhagic and ischem...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369066/ https://www.ncbi.nlm.nih.gov/pubmed/28245607 http://dx.doi.org/10.3390/ijerph14030230 |
_version_ | 1782518054676070400 |
---|---|
author | Liu, Shih-Wei Huang, Liang-Chung Chung, Wu-Fu Chang, Hsuan-Kan Wu, Jau-Ching Chen, Li-Fu Chen, Yu-Chun Huang, Wen-Cheng Cheng, Henrich Lo, Su-Shun |
author_facet | Liu, Shih-Wei Huang, Liang-Chung Chung, Wu-Fu Chang, Hsuan-Kan Wu, Jau-Ching Chen, Li-Fu Chen, Yu-Chun Huang, Wen-Cheng Cheng, Henrich Lo, Su-Shun |
author_sort | Liu, Shih-Wei |
collection | PubMed |
description | Long-term morbidities can develop after traumatic brain injury (TBI). Some studies have suggested that the risk of stroke is higher after TBI, but the association between concussion and stroke remains unclear. Using a national cohort, the authors analyzed the incidence of both hemorrhagic and ischemic strokes in patients with previous concussion. A representative cohort of approximately one million people was followed up for four years. Patients with new-onset concussion were identified (n = 13,652) as the concussion group. Subsequently, the incidence rates of later stroke events in the concussion group were compared to a sex-, age- and propensity score–matched comparison group (n = 13,652). The overall incidence rate of stroke in the concussion group was higher than that of the comparison group (9.63 versus 6.52 per 1000 person-years, p < 0.001). Significantly higher stroke risk was observed in the concussion group than in the comparison group (crude hazard ratio 1.48, p < 0.001; adjusted HR 1.65, p < 0.001). In the concussion group, the cumulative incidence rates of both ischemic stroke and hemorrhagic stroke were higher than those of the comparison group (8.9% vs. 5.8% and 2.7% vs. 1.6%, respectively, both p < 0.001). Concussion is an independent risk factor for both ischemic and hemorrhagic strokes. Prevention and monitoring strategies of stroke are therefore suggested for patients who have experienced concussion. |
format | Online Article Text |
id | pubmed-5369066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53690662017-04-05 Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study Liu, Shih-Wei Huang, Liang-Chung Chung, Wu-Fu Chang, Hsuan-Kan Wu, Jau-Ching Chen, Li-Fu Chen, Yu-Chun Huang, Wen-Cheng Cheng, Henrich Lo, Su-Shun Int J Environ Res Public Health Article Long-term morbidities can develop after traumatic brain injury (TBI). Some studies have suggested that the risk of stroke is higher after TBI, but the association between concussion and stroke remains unclear. Using a national cohort, the authors analyzed the incidence of both hemorrhagic and ischemic strokes in patients with previous concussion. A representative cohort of approximately one million people was followed up for four years. Patients with new-onset concussion were identified (n = 13,652) as the concussion group. Subsequently, the incidence rates of later stroke events in the concussion group were compared to a sex-, age- and propensity score–matched comparison group (n = 13,652). The overall incidence rate of stroke in the concussion group was higher than that of the comparison group (9.63 versus 6.52 per 1000 person-years, p < 0.001). Significantly higher stroke risk was observed in the concussion group than in the comparison group (crude hazard ratio 1.48, p < 0.001; adjusted HR 1.65, p < 0.001). In the concussion group, the cumulative incidence rates of both ischemic stroke and hemorrhagic stroke were higher than those of the comparison group (8.9% vs. 5.8% and 2.7% vs. 1.6%, respectively, both p < 0.001). Concussion is an independent risk factor for both ischemic and hemorrhagic strokes. Prevention and monitoring strategies of stroke are therefore suggested for patients who have experienced concussion. MDPI 2017-02-25 2017-03 /pmc/articles/PMC5369066/ /pubmed/28245607 http://dx.doi.org/10.3390/ijerph14030230 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Shih-Wei Huang, Liang-Chung Chung, Wu-Fu Chang, Hsuan-Kan Wu, Jau-Ching Chen, Li-Fu Chen, Yu-Chun Huang, Wen-Cheng Cheng, Henrich Lo, Su-Shun Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title | Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title_full | Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title_fullStr | Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title_full_unstemmed | Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title_short | Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study |
title_sort | increased risk of stroke in patients of concussion: a nationwide cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369066/ https://www.ncbi.nlm.nih.gov/pubmed/28245607 http://dx.doi.org/10.3390/ijerph14030230 |
work_keys_str_mv | AT liushihwei increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT huangliangchung increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT chungwufu increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT changhsuankan increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT wujauching increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT chenlifu increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT chenyuchun increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT huangwencheng increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT chenghenrich increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy AT losushun increasedriskofstrokeinpatientsofconcussionanationwidecohortstudy |