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Oral Health Status of Patients with Lysosomal Storage Diseases in Poland

Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty...

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Autores principales: Drążewski, Damian, Grzymisławska, Małgorzata, Korybalska, Katarzyna, Czepulis, Natasza, Grzymisławski, Marian, Witowski, Janusz, Surdacka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369117/
https://www.ncbi.nlm.nih.gov/pubmed/28282939
http://dx.doi.org/10.3390/ijerph14030281
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author Drążewski, Damian
Grzymisławska, Małgorzata
Korybalska, Katarzyna
Czepulis, Natasza
Grzymisławski, Marian
Witowski, Janusz
Surdacka, Anna
author_facet Drążewski, Damian
Grzymisławska, Małgorzata
Korybalska, Katarzyna
Czepulis, Natasza
Grzymisławski, Marian
Witowski, Janusz
Surdacka, Anna
author_sort Drążewski, Damian
collection PubMed
description Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty-six children and young adults with various forms of LSDs were examined. The data were compared with those from age- and sex-matched healthy controls. Exemplary cases were presented to highlight typical problems in oral care associated with LSDs. When possible, saliva was collected and analyzed for total protein, inflammatory mediators, and antioxidant status. Generally, patients with LSDs had significantly higher prevalence of caries, inferior gingival status, and inadequate oral hygiene. The severity of oral health impairment in mucopolysaccaridoses, the most common LSD in Poland, was similar to that seen in patients with mannosidoses or Pompe disease. Saliva could be collected only from few less handicapped patients. In MPS, it did not appear to differ significantly from the controls, but in patients with Pompe disease it contained lower concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1), but higher levels of tumor necrosis factor receptors 1 and 2 (TNF-R1, TNF-R2) and myeloperoxidase (MPO). In conclusion, Polish patients with LSDs have an inadequate level of oral hygiene and substantially deteriorated oral health.
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spelling pubmed-53691172017-04-05 Oral Health Status of Patients with Lysosomal Storage Diseases in Poland Drążewski, Damian Grzymisławska, Małgorzata Korybalska, Katarzyna Czepulis, Natasza Grzymisławski, Marian Witowski, Janusz Surdacka, Anna Int J Environ Res Public Health Article Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty-six children and young adults with various forms of LSDs were examined. The data were compared with those from age- and sex-matched healthy controls. Exemplary cases were presented to highlight typical problems in oral care associated with LSDs. When possible, saliva was collected and analyzed for total protein, inflammatory mediators, and antioxidant status. Generally, patients with LSDs had significantly higher prevalence of caries, inferior gingival status, and inadequate oral hygiene. The severity of oral health impairment in mucopolysaccaridoses, the most common LSD in Poland, was similar to that seen in patients with mannosidoses or Pompe disease. Saliva could be collected only from few less handicapped patients. In MPS, it did not appear to differ significantly from the controls, but in patients with Pompe disease it contained lower concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1), but higher levels of tumor necrosis factor receptors 1 and 2 (TNF-R1, TNF-R2) and myeloperoxidase (MPO). In conclusion, Polish patients with LSDs have an inadequate level of oral hygiene and substantially deteriorated oral health. MDPI 2017-03-09 2017-03 /pmc/articles/PMC5369117/ /pubmed/28282939 http://dx.doi.org/10.3390/ijerph14030281 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Drążewski, Damian
Grzymisławska, Małgorzata
Korybalska, Katarzyna
Czepulis, Natasza
Grzymisławski, Marian
Witowski, Janusz
Surdacka, Anna
Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title_full Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title_fullStr Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title_full_unstemmed Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title_short Oral Health Status of Patients with Lysosomal Storage Diseases in Poland
title_sort oral health status of patients with lysosomal storage diseases in poland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369117/
https://www.ncbi.nlm.nih.gov/pubmed/28282939
http://dx.doi.org/10.3390/ijerph14030281
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