Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility

We analyzed 1,900 Turkish Behçet’s disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated single nucleotide polymorphism (SNP) was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three novel loci, IL1A-IL1B, IRF8, and CEBPB-PT...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeuchi, Masaki, Mizuki, Nobuhisa, Meguro, Akira, Ombrello, Michael J., Kirino, Yohei, Satorius, Colleen, Le, Julie, Blake, Mary, Erer, Burak, Kawagoe, Tatsukata, Ustek, Duran, Tugal-Tutkun, Ilknur, Seyahi, Emire, Ozyazgan, Yilmaz, Sousa, Inês, Davatchi, Fereydoun, Francisco, Vânia, Shahram, Farhad, Abdollahi, Bahar Sadeghi, Nadji, Abdolhadi, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Ohno, Shigeaki, Ueda, Atsuhisa, Ishigatsubo, Yoshiaki, Gadina, Massimo, Oliveira, Sofia A., Gül, Ahmet, Kastner, Daniel L., Remmers, Elaine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369770/
https://www.ncbi.nlm.nih.gov/pubmed/28166214
http://dx.doi.org/10.1038/ng.3786

Ejemplares similares

Ejemplares similares