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Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection

Adjuvant transarterial chemoembolization (TACE) is a major option for postoperative hepatocellular carcinoma (HCC) patients with recurrence risk factors. However, individualized predictive models for subgroup of these patients are limited. This study aimed to develop a prognostic nomogram for patien...

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Autores principales: Jing, Chu-Yu, Fu, Yi-Peng, Zheng, Su-Su, Yi, Yong, Shen, Hu-Jia, Huang, Jin-Long, Xu, Xin, Lin, Jia-Jia, Zhou, Jian, Fan, Jia, Ren, Zheng-Gang, Qiu, Shuang-Jian, Zhang, Bo-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369882/
https://www.ncbi.nlm.nih.gov/pubmed/28296727
http://dx.doi.org/10.1097/MD.0000000000006140
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author Jing, Chu-Yu
Fu, Yi-Peng
Zheng, Su-Su
Yi, Yong
Shen, Hu-Jia
Huang, Jin-Long
Xu, Xin
Lin, Jia-Jia
Zhou, Jian
Fan, Jia
Ren, Zheng-Gang
Qiu, Shuang-Jian
Zhang, Bo-Heng
author_facet Jing, Chu-Yu
Fu, Yi-Peng
Zheng, Su-Su
Yi, Yong
Shen, Hu-Jia
Huang, Jin-Long
Xu, Xin
Lin, Jia-Jia
Zhou, Jian
Fan, Jia
Ren, Zheng-Gang
Qiu, Shuang-Jian
Zhang, Bo-Heng
author_sort Jing, Chu-Yu
collection PubMed
description Adjuvant transarterial chemoembolization (TACE) is a major option for postoperative hepatocellular carcinoma (HCC) patients with recurrence risk factors. However, individualized predictive models for subgroup of these patients are limited. This study aimed to develop a prognostic nomogram for patients with HCC underwent adjuvant TACE following curative resection. A cohort comprising 144 HCC patients who received adjuvant TACE following curative resection in the Zhongshan Hospital were analyzed. The nomogram was formulated based on independent prognostic indicators for overall survival (OS). The performance of the nomogram was evaluated by the concordance index (C-index), calibration curve, and decision curve analysis (DCA) and compared with the conventional staging systems. The results were validated in an independent cohort of 86 patients with the same inclusion criteria. Serum alpha-fetoprotein (AFP), hyper-sensitive C-reactive protein (hs-CRP), incomplete tumor encapsulation, and double positive staining of Cytokeratin 7 and Cytokeratin 19 on tumor cells were identified as independent predictors for OS. The C-indices of the nomogram for OS prediction in the training cohort and validation cohort were 0.787 (95%CI 0.775–0.799) and 0.714 (95%CI 0.695–0.733), respectively. In both the training and validation cohorts, the calibration plot showed good consistency between the nomogram-predicted and the observed survival. Furthermore, the established nomogram was superior to the conventional staging systems in terms of C-index and clinical net benefit on DCA. The proposed nomogram provided an accurate prediction on risk stratification for HCC patients underwent adjuvant TACE following curative resection.
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spelling pubmed-53698822017-03-31 Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection Jing, Chu-Yu Fu, Yi-Peng Zheng, Su-Su Yi, Yong Shen, Hu-Jia Huang, Jin-Long Xu, Xin Lin, Jia-Jia Zhou, Jian Fan, Jia Ren, Zheng-Gang Qiu, Shuang-Jian Zhang, Bo-Heng Medicine (Baltimore) 5700 Adjuvant transarterial chemoembolization (TACE) is a major option for postoperative hepatocellular carcinoma (HCC) patients with recurrence risk factors. However, individualized predictive models for subgroup of these patients are limited. This study aimed to develop a prognostic nomogram for patients with HCC underwent adjuvant TACE following curative resection. A cohort comprising 144 HCC patients who received adjuvant TACE following curative resection in the Zhongshan Hospital were analyzed. The nomogram was formulated based on independent prognostic indicators for overall survival (OS). The performance of the nomogram was evaluated by the concordance index (C-index), calibration curve, and decision curve analysis (DCA) and compared with the conventional staging systems. The results were validated in an independent cohort of 86 patients with the same inclusion criteria. Serum alpha-fetoprotein (AFP), hyper-sensitive C-reactive protein (hs-CRP), incomplete tumor encapsulation, and double positive staining of Cytokeratin 7 and Cytokeratin 19 on tumor cells were identified as independent predictors for OS. The C-indices of the nomogram for OS prediction in the training cohort and validation cohort were 0.787 (95%CI 0.775–0.799) and 0.714 (95%CI 0.695–0.733), respectively. In both the training and validation cohorts, the calibration plot showed good consistency between the nomogram-predicted and the observed survival. Furthermore, the established nomogram was superior to the conventional staging systems in terms of C-index and clinical net benefit on DCA. The proposed nomogram provided an accurate prediction on risk stratification for HCC patients underwent adjuvant TACE following curative resection. Wolters Kluwer Health 2017-03-24 /pmc/articles/PMC5369882/ /pubmed/28296727 http://dx.doi.org/10.1097/MD.0000000000006140 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Jing, Chu-Yu
Fu, Yi-Peng
Zheng, Su-Su
Yi, Yong
Shen, Hu-Jia
Huang, Jin-Long
Xu, Xin
Lin, Jia-Jia
Zhou, Jian
Fan, Jia
Ren, Zheng-Gang
Qiu, Shuang-Jian
Zhang, Bo-Heng
Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title_full Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title_fullStr Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title_full_unstemmed Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title_short Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
title_sort prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369882/
https://www.ncbi.nlm.nih.gov/pubmed/28296727
http://dx.doi.org/10.1097/MD.0000000000006140
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