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Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis

BACKGROUND: Methotrexate (MTX) is widely used and considered a first-line disease modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). However, 10% to 30% of patients discontinue therapy within a year of starting the treatment, usually because of undesirable side effe...

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Detalles Bibliográficos
Autores principales:	Qiu, Qi, Huang, Jing, Lin, Yang, Shu, Xiaoming, Fan, Huizheng, Tu, Zhihua, Zhou, Youwen, Xiao, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2017
Materias:	4400
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369916/ https://www.ncbi.nlm.nih.gov/pubmed/28296761 http://dx.doi.org/10.1097/MD.0000000000006337

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