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Efficacy of fresh packed red blood transfusion in organophosphate poisoning

The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and...

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Autores principales: Bao, Hang-xing, Tong, Pei-jian, Li, Cai-xia, Du, Jing, Chen, Bing-yu, Huang, Zhi-hui, Wang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369934/
https://www.ncbi.nlm.nih.gov/pubmed/28296779
http://dx.doi.org/10.1097/MD.0000000000006375
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author Bao, Hang-xing
Tong, Pei-jian
Li, Cai-xia
Du, Jing
Chen, Bing-yu
Huang, Zhi-hui
Wang, Ying
author_facet Bao, Hang-xing
Tong, Pei-jian
Li, Cai-xia
Du, Jing
Chen, Bing-yu
Huang, Zhi-hui
Wang, Ying
author_sort Bao, Hang-xing
collection PubMed
description The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and compare the therapeutic effects of RBCs at different storage times. Patients diagnosed with OP poisoning were included in this prospective study. Fresh RBCs (packed RBCs stored less than 10 days) and longer-storage RBCs (stored more than 10 days but less than 35 days) were randomly transfused or not into OP poisoning patients. Cholinesterase (ChE) levels in blood, atropine usage and durations, pralidoxime durations were measured. We found that both fresh and longer-storage RBCs (200–400 mL) significantly increased blood ChE levels 6 hours after transfusion, shortened the duration for ChE recovery and length of hospital stay, and reduced the usage of atropine and pralidoxime. In addition, fresh RBCs demonstrated stronger therapeutic effects than longer-storage RBCs. Packed RBCs might be an alternative approach in patients with OP poisoning, especially during early stages.
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spelling pubmed-53699342017-03-31 Efficacy of fresh packed red blood transfusion in organophosphate poisoning Bao, Hang-xing Tong, Pei-jian Li, Cai-xia Du, Jing Chen, Bing-yu Huang, Zhi-hui Wang, Ying Medicine (Baltimore) 7200 The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and compare the therapeutic effects of RBCs at different storage times. Patients diagnosed with OP poisoning were included in this prospective study. Fresh RBCs (packed RBCs stored less than 10 days) and longer-storage RBCs (stored more than 10 days but less than 35 days) were randomly transfused or not into OP poisoning patients. Cholinesterase (ChE) levels in blood, atropine usage and durations, pralidoxime durations were measured. We found that both fresh and longer-storage RBCs (200–400 mL) significantly increased blood ChE levels 6 hours after transfusion, shortened the duration for ChE recovery and length of hospital stay, and reduced the usage of atropine and pralidoxime. In addition, fresh RBCs demonstrated stronger therapeutic effects than longer-storage RBCs. Packed RBCs might be an alternative approach in patients with OP poisoning, especially during early stages. Wolters Kluwer Health 2017-03-24 /pmc/articles/PMC5369934/ /pubmed/28296779 http://dx.doi.org/10.1097/MD.0000000000006375 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 7200
Bao, Hang-xing
Tong, Pei-jian
Li, Cai-xia
Du, Jing
Chen, Bing-yu
Huang, Zhi-hui
Wang, Ying
Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title_full Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title_fullStr Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title_full_unstemmed Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title_short Efficacy of fresh packed red blood transfusion in organophosphate poisoning
title_sort efficacy of fresh packed red blood transfusion in organophosphate poisoning
topic 7200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369934/
https://www.ncbi.nlm.nih.gov/pubmed/28296779
http://dx.doi.org/10.1097/MD.0000000000006375
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