Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway

Here we provide evidence to link sub-lethal oxidative stress to lysosome biogenesis. Exposure of cells to sub-lethal concentrations of exogenously added hydrogen peroxide resulted in cytosol to nuclear translocation of the Transcription Factor EB (TFEB), the master controller of lysosome biogenesis...

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Detalles Bibliográficos
Autores principales: Leow, San Min, Chua, Shu Xian Serene, Venkatachalam, Gireedhar, Shen, Liang, Luo, Le, Clement, Marie-Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Autophagy and Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/
https://www.ncbi.nlm.nih.gov/pubmed/28002813
http://dx.doi.org/10.18632/oncotarget.14016

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