Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement of complementarity between...

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Detalles Bibliográficos
Autores principales: Pallis, Monica, Burrows, Francis, Ryan, Jeremy, Grundy, Martin, Seedhouse, Claire, Abdul-Aziz, Amina, Montero, Joan, Letai, Anthony, Russell, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369958/
https://www.ncbi.nlm.nih.gov/pubmed/27092880
http://dx.doi.org/10.18632/oncotarget.8742

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