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The complicated role of venous drainage on the survival of arterialized venous flaps

The arterialized venous flap (AVF) has been gradually popularized in clinical settings; however, its survival is still inconsistent and the role of venous drainage remains elusive. In this study, we aimed to investigate the role of venous drainage on the flap survival of arterialized venous flaps. A...

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Autores principales: Weng, Weidong, Zhang, Feng, Zhao, Bin, Wu, Zhipeng, Gao, Weiyang, Li, Zhijie, Yan, Hede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369972/
https://www.ncbi.nlm.nih.gov/pubmed/28145882
http://dx.doi.org/10.18632/oncotarget.14845
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author Weng, Weidong
Zhang, Feng
Zhao, Bin
Wu, Zhipeng
Gao, Weiyang
Li, Zhijie
Yan, Hede
author_facet Weng, Weidong
Zhang, Feng
Zhao, Bin
Wu, Zhipeng
Gao, Weiyang
Li, Zhijie
Yan, Hede
author_sort Weng, Weidong
collection PubMed
description The arterialized venous flap (AVF) has been gradually popularized in clinical settings; however, its survival is still inconsistent and the role of venous drainage remains elusive. In this study, we aimed to investigate the role of venous drainage on the flap survival of arterialized venous flaps. An arterialized venous flap was outlined symmetrically in the rabbit abdomen. The arterial perfusion flap with a unilateral vascular pedicle was taken as the control group and three other experimental groups (I, II and III) were designed based on the number of drainage veins (n = 1, 2 and 3 in the three groups, respectively). Compared with the control group, significant venous congestion was noted in all the experimental groups and the most severe one was seen in group I; while no statistical difference was observed between groups II and III. Similar results regarding blood perfusion state, epidermal metabolite levels and flap survival status were obtained among the three groups. These findings suggested that venous drainage is vital in the survival of the flap, but unlike in the arterial perfusion flaps, the problem of venous congestion can only be partially solved by increasing the number of draining veins. Further studies are warranted to gain insight into this complicated issue.
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spelling pubmed-53699722017-04-17 The complicated role of venous drainage on the survival of arterialized venous flaps Weng, Weidong Zhang, Feng Zhao, Bin Wu, Zhipeng Gao, Weiyang Li, Zhijie Yan, Hede Oncotarget Research Paper The arterialized venous flap (AVF) has been gradually popularized in clinical settings; however, its survival is still inconsistent and the role of venous drainage remains elusive. In this study, we aimed to investigate the role of venous drainage on the flap survival of arterialized venous flaps. An arterialized venous flap was outlined symmetrically in the rabbit abdomen. The arterial perfusion flap with a unilateral vascular pedicle was taken as the control group and three other experimental groups (I, II and III) were designed based on the number of drainage veins (n = 1, 2 and 3 in the three groups, respectively). Compared with the control group, significant venous congestion was noted in all the experimental groups and the most severe one was seen in group I; while no statistical difference was observed between groups II and III. Similar results regarding blood perfusion state, epidermal metabolite levels and flap survival status were obtained among the three groups. These findings suggested that venous drainage is vital in the survival of the flap, but unlike in the arterial perfusion flaps, the problem of venous congestion can only be partially solved by increasing the number of draining veins. Further studies are warranted to gain insight into this complicated issue. Impact Journals LLC 2017-01-27 /pmc/articles/PMC5369972/ /pubmed/28145882 http://dx.doi.org/10.18632/oncotarget.14845 Text en Copyright: © 2017 Weng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Weng, Weidong
Zhang, Feng
Zhao, Bin
Wu, Zhipeng
Gao, Weiyang
Li, Zhijie
Yan, Hede
The complicated role of venous drainage on the survival of arterialized venous flaps
title The complicated role of venous drainage on the survival of arterialized venous flaps
title_full The complicated role of venous drainage on the survival of arterialized venous flaps
title_fullStr The complicated role of venous drainage on the survival of arterialized venous flaps
title_full_unstemmed The complicated role of venous drainage on the survival of arterialized venous flaps
title_short The complicated role of venous drainage on the survival of arterialized venous flaps
title_sort complicated role of venous drainage on the survival of arterialized venous flaps
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369972/
https://www.ncbi.nlm.nih.gov/pubmed/28145882
http://dx.doi.org/10.18632/oncotarget.14845
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