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HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation
HIPK2 is a Y-regulated S/T kinase involved in various cellular processes, including cell-fate decision during development and DNA damage response. Cis-autophosphorylation in the activation-loop and trans-autophosphorylation at several S/T sites along the protein are required for HIPK2 activation, su...
Autores principales: | Verdina, Alessandra, Di Rocco, Giuliana, Virdia, Ilaria, Monteonofrio, Laura, Gatti, Veronica, Policicchio, Eleonora, Bruselles, Alessandro, Tartaglia, Marco, Soddu, Silvia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369998/ https://www.ncbi.nlm.nih.gov/pubmed/28060750 http://dx.doi.org/10.18632/oncotarget.14421 |
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