Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation

Excessive deposition of extracellular matrix (ECM) in the glomerulus contributed by mesangial cells is the hallmark of diabetic nephropathy, eventually leading to glomerulosclerosis. In this study, we examined the regulatory signals involved in the high glucose (HG)-induced overproduction of ECM in...

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Detalles Bibliográficos
Autores principales: Sheu, Meei-Ling, Shen, Chin-Chang, Jheng, Jia-Rong, Chiang, Chih-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370011/
https://www.ncbi.nlm.nih.gov/pubmed/28129651
http://dx.doi.org/10.18632/oncotarget.14808

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