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Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response

During DNA double strand breaks (DSBs) repair, coordinated activation of phosphatidylinositol 3-kinase (PI3K)-like kinases can activate p53 signaling pathway. Recent findings have identified novel interplays among these kinases demonstrating amplified first p53 pulses under DNA-PK inhibition. Howeve...

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Detalles Bibliográficos
Autores principales:	Sun, Tingzhe, Li, Xinda, Shen, Pingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370026/ https://www.ncbi.nlm.nih.gov/pubmed/28177883 http://dx.doi.org/10.18632/oncotarget.15062

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