Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes...

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Detalles Bibliográficos
Autores principales: Kumar, Ramiya, Mota, Linda C., Litoff, Elizabeth J., Rooney, John P., Boswell, W. Tyler, Courter, Elliott, Henderson, Charles M., Hernandez, Juan P., Corton, J. Christopher, Moore, David D., Baldwin, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370058/
https://www.ncbi.nlm.nih.gov/pubmed/28350814
http://dx.doi.org/10.1371/journal.pone.0174355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370058/
https://www.ncbi.nlm.nih.gov/pubmed/28350814
http://dx.doi.org/10.1371/journal.pone.0174355

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