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Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons

The neurotrophic factor neuregulin 1 (NRG1) regulates neuronal development, glial differentiation, and excitatory synapse maturation. NRG1 is synthesized as a membrane-anchored precursor and is then liberated by proteolytic processing or exocytosis. Mature NRG1 then binds to its receptors expressed...

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Detalles Bibliográficos
Autores principales:	Iwakura, Yuriko, Wang, Ran, Inamura, Naoko, Araki, Kazuaki, Higashiyama, Shigeki, Takei, Nobuyuki, Nawa, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370147/ https://www.ncbi.nlm.nih.gov/pubmed/28350885 http://dx.doi.org/10.1371/journal.pone.0174780

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