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Gender-based differences in the relationship between fatty liver disease and atherosclerosis

BACKGROUND: Carotid intima–media thickness (CIMT) is a surrogate of subclinical atherosclerosis. Fatty liver disease is also linked to increased risk of cardiovascular events. The aim of this study was to evaluate the association between fatty liver disease and CIMT according to gender. METHODS: Pat...

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Autores principales: Kim, Hyun-Jin, Lim, Chae-Wan, Lee, Jae hyuk, Park, Hyung-Bok, Suh, Yongsung, Cho, Yoon-Hyeong, Choi, Tae-Young, Hwang, Eui-Seok, Cho, Deok-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370319/
https://www.ncbi.nlm.nih.gov/pubmed/26972662
http://dx.doi.org/10.5830/CVJA-2016-014
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author Kim, Hyun-Jin
Lim, Chae-Wan
Lee, Jae hyuk
Park, Hyung-Bok
Suh, Yongsung
Cho, Yoon-Hyeong
Choi, Tae-Young
Hwang, Eui-Seok
Cho, Deok-Kyu
Kim, Hyun-Jin
author_facet Kim, Hyun-Jin
Lim, Chae-Wan
Lee, Jae hyuk
Park, Hyung-Bok
Suh, Yongsung
Cho, Yoon-Hyeong
Choi, Tae-Young
Hwang, Eui-Seok
Cho, Deok-Kyu
Kim, Hyun-Jin
author_sort Kim, Hyun-Jin
collection PubMed
description BACKGROUND: Carotid intima–media thickness (CIMT) is a surrogate of subclinical atherosclerosis. Fatty liver disease is also linked to increased risk of cardiovascular events. The aim of this study was to evaluate the association between fatty liver disease and CIMT according to gender. METHODS: Patients who had undergone carotid and abdominal ultrasound between June 2011 and December 2013 were retrospectively evaluated. The differences between the CIMT values measured in the common carotid artery and the prevalence of carotid plaque in patients with fatty liver disease and those with normal livers were investigated. RESULTS: Out of a total of 1 121 patients, the men had more fatty liver disease than the women. The mean CIMT of the men was significantly higher than that of the women, and the men had more plaque than the women. The women with fatty liver disease had a significantly higher mean CIMT value and more plaque than the women with normal livers. The differences between the men with fatty liver and those with normal livers in mean CIMT values and in the prevalence of plaque were not significant. In the women, multivariate analysis showed that fatty liver disease was independently associated with subclinical atherosclerosis [adjusted hazards ratio (HR) 1.65, 95% confidence interval (CI) 1.007–2.697, p = 0.047]. CONCLUSIONS: The men had more fatty liver disease, carotid plaque and higher CIMT values than the women. Fatty liver disease was a useful predictor of atherosclerosis, especially for the female study patients.
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spelling pubmed-53703192017-04-12 Gender-based differences in the relationship between fatty liver disease and atherosclerosis Kim, Hyun-Jin Lim, Chae-Wan Lee, Jae hyuk Park, Hyung-Bok Suh, Yongsung Cho, Yoon-Hyeong Choi, Tae-Young Hwang, Eui-Seok Cho, Deok-Kyu Kim, Hyun-Jin Cardiovasc J Afr Cardiovascular Topics BACKGROUND: Carotid intima–media thickness (CIMT) is a surrogate of subclinical atherosclerosis. Fatty liver disease is also linked to increased risk of cardiovascular events. The aim of this study was to evaluate the association between fatty liver disease and CIMT according to gender. METHODS: Patients who had undergone carotid and abdominal ultrasound between June 2011 and December 2013 were retrospectively evaluated. The differences between the CIMT values measured in the common carotid artery and the prevalence of carotid plaque in patients with fatty liver disease and those with normal livers were investigated. RESULTS: Out of a total of 1 121 patients, the men had more fatty liver disease than the women. The mean CIMT of the men was significantly higher than that of the women, and the men had more plaque than the women. The women with fatty liver disease had a significantly higher mean CIMT value and more plaque than the women with normal livers. The differences between the men with fatty liver and those with normal livers in mean CIMT values and in the prevalence of plaque were not significant. In the women, multivariate analysis showed that fatty liver disease was independently associated with subclinical atherosclerosis [adjusted hazards ratio (HR) 1.65, 95% confidence interval (CI) 1.007–2.697, p = 0.047]. CONCLUSIONS: The men had more fatty liver disease, carotid plaque and higher CIMT values than the women. Fatty liver disease was a useful predictor of atherosclerosis, especially for the female study patients. Clinics Cardive Publishing 2016 /pmc/articles/PMC5370319/ /pubmed/26972662 http://dx.doi.org/10.5830/CVJA-2016-014 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Kim, Hyun-Jin
Lim, Chae-Wan
Lee, Jae hyuk
Park, Hyung-Bok
Suh, Yongsung
Cho, Yoon-Hyeong
Choi, Tae-Young
Hwang, Eui-Seok
Cho, Deok-Kyu
Kim, Hyun-Jin
Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title_full Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title_fullStr Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title_full_unstemmed Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title_short Gender-based differences in the relationship between fatty liver disease and atherosclerosis
title_sort gender-based differences in the relationship between fatty liver disease and atherosclerosis
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370319/
https://www.ncbi.nlm.nih.gov/pubmed/26972662
http://dx.doi.org/10.5830/CVJA-2016-014
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