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Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Development of submodels of organs within physiologically-based pharmacokinetic (PBPK) principles and beyond simple perfusion limitations may be challenging because of underdeveloped in vitro-in vivo extrapolation approaches or lack of suitable clinical data for model refinement. However, advantage...

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Detalles Bibliográficos
Autores principales:	Scotcher, Daniel, Jones, Christopher R., Galetin, Aleksandra, Rostami-Hodjegan, Amin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:	Metabolism, Transport, and Pharmacogenomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370399/ https://www.ncbi.nlm.nih.gov/pubmed/28057840 http://dx.doi.org/10.1124/jpet.116.237438

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