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On the Uniqueness of the Standard Genetic Code
In this work, we determine the biological and mathematical properties that are sufficient and necessary to uniquely determine both the primeval RNY (purine-any base-pyrimidine) code and the standard genetic code (SGC). These properties are: the evolution of the SGC from the RNY code; the degeneracy...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370407/ https://www.ncbi.nlm.nih.gov/pubmed/28208827 http://dx.doi.org/10.3390/life7010007 |
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author | Zamudio, Gabriel S. José, Marco V. |
author_facet | Zamudio, Gabriel S. José, Marco V. |
author_sort | Zamudio, Gabriel S. |
collection | PubMed |
description | In this work, we determine the biological and mathematical properties that are sufficient and necessary to uniquely determine both the primeval RNY (purine-any base-pyrimidine) code and the standard genetic code (SGC). These properties are: the evolution of the SGC from the RNY code; the degeneracy of both codes, and the non-degeneracy of the assignments of aminoacyl-tRNA synthetases (aaRSs) to amino acids; the wobbling property; the consideration that glycine was the first amino acid; the topological and symmetrical properties of both codes. |
format | Online Article Text |
id | pubmed-5370407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53704072017-04-05 On the Uniqueness of the Standard Genetic Code Zamudio, Gabriel S. José, Marco V. Life (Basel) Article In this work, we determine the biological and mathematical properties that are sufficient and necessary to uniquely determine both the primeval RNY (purine-any base-pyrimidine) code and the standard genetic code (SGC). These properties are: the evolution of the SGC from the RNY code; the degeneracy of both codes, and the non-degeneracy of the assignments of aminoacyl-tRNA synthetases (aaRSs) to amino acids; the wobbling property; the consideration that glycine was the first amino acid; the topological and symmetrical properties of both codes. MDPI 2017-02-13 /pmc/articles/PMC5370407/ /pubmed/28208827 http://dx.doi.org/10.3390/life7010007 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zamudio, Gabriel S. José, Marco V. On the Uniqueness of the Standard Genetic Code |
title | On the Uniqueness of the Standard Genetic Code |
title_full | On the Uniqueness of the Standard Genetic Code |
title_fullStr | On the Uniqueness of the Standard Genetic Code |
title_full_unstemmed | On the Uniqueness of the Standard Genetic Code |
title_short | On the Uniqueness of the Standard Genetic Code |
title_sort | on the uniqueness of the standard genetic code |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370407/ https://www.ncbi.nlm.nih.gov/pubmed/28208827 http://dx.doi.org/10.3390/life7010007 |
work_keys_str_mv | AT zamudiogabriels ontheuniquenessofthestandardgeneticcode AT josemarcov ontheuniquenessofthestandardgeneticcode |