Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?

BACKGROUND: To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer. METHODS: The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synapto...

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Autores principales: Chen, Yue, Liu, Fang, Meng, Qingkai, Ma, Siping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370452/
https://www.ncbi.nlm.nih.gov/pubmed/28351413
http://dx.doi.org/10.1186/s12957-017-1139-y
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author Chen, Yue
Liu, Fang
Meng, Qingkai
Ma, Siping
author_facet Chen, Yue
Liu, Fang
Meng, Qingkai
Ma, Siping
author_sort Chen, Yue
collection PubMed
description BACKGROUND: To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer. METHODS: The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death. RESULTS: Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006). CONCLUSIONS: Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis.
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spelling pubmed-53704522017-03-30 Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer? Chen, Yue Liu, Fang Meng, Qingkai Ma, Siping World J Surg Oncol Research BACKGROUND: To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer. METHODS: The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death. RESULTS: Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006). CONCLUSIONS: Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis. BioMed Central 2017-03-28 /pmc/articles/PMC5370452/ /pubmed/28351413 http://dx.doi.org/10.1186/s12957-017-1139-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Yue
Liu, Fang
Meng, Qingkai
Ma, Siping
Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title_full Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title_fullStr Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title_full_unstemmed Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title_short Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
title_sort is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370452/
https://www.ncbi.nlm.nih.gov/pubmed/28351413
http://dx.doi.org/10.1186/s12957-017-1139-y
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