Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

BACKGROUND: Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is unchara...

Descripción completa

Detalles Bibliográficos
Autores principales: Cole, John J., Robertson, Neil A., Rather, Mohammed Iqbal, Thomson, John P., McBryan, Tony, Sproul, Duncan, Wang, Tina, Brock, Claire, Clark, William, Ideker, Trey, Meehan, Richard R., Miller, Richard A., Brown-Borg, Holly M., Adams, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370462/
https://www.ncbi.nlm.nih.gov/pubmed/28351383
http://dx.doi.org/10.1186/s13059-017-1185-3

Ejemplares similares

Ejemplares similares