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Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report

INTRODUCTION: Hepatoid adenocarcinoma (HAC) is a rare neoplasm with a striking morphologic similarity to hepatocellular carcinoma. The most common sites of HAC are the stomach, lung, and pancreas. CASE REPORT: Here we report a rare case of HAC arising from the heterotopic pancreas (Heinrich type II)...

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Autores principales: Tong, Ling, Pan, Huaxiong, He, Jun, Weng, Mixia, Zheng, Liduan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370778/
https://www.ncbi.nlm.nih.gov/pubmed/27537551
http://dx.doi.org/10.1097/MD.0000000000004067
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author Tong, Ling
Pan, Huaxiong
He, Jun
Weng, Mixia
Zheng, Liduan
author_facet Tong, Ling
Pan, Huaxiong
He, Jun
Weng, Mixia
Zheng, Liduan
author_sort Tong, Ling
collection PubMed
description INTRODUCTION: Hepatoid adenocarcinoma (HAC) is a rare neoplasm with a striking morphologic similarity to hepatocellular carcinoma. The most common sites of HAC are the stomach, lung, and pancreas. CASE REPORT: Here we report a rare case of HAC arising from the heterotopic pancreas (Heinrich type II) in the ileum with lymph node metastasis. A 56-year-old man was admitted to our hospital presenting with bloody stools under no obvious predisposing causes. The colonoscopy and the gastroscopy showed no pathological findings. A computed tomography scan showed an intussusception of ileum. Then partial resection of ileum was performed with end-to-end anastomosis and appendectomy. Histopathological examination showed a malignant transformation of heterotopic pancreas (Heinrich type II) in the ileum. We made the diagnosis of HAC based on clinical pathological features and immunochemical staining. The patient received chemotherapy and died 9 months later. CONCLUSION: To our best knowledge, this is the first reported case of HAC originated from a heterotopic pancreas in the ileum. The clinical pathological features and immunochemical staining are important for correct diagnosis of HAC.
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spelling pubmed-53707782017-03-31 Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report Tong, Ling Pan, Huaxiong He, Jun Weng, Mixia Zheng, Liduan Medicine (Baltimore) 4500 INTRODUCTION: Hepatoid adenocarcinoma (HAC) is a rare neoplasm with a striking morphologic similarity to hepatocellular carcinoma. The most common sites of HAC are the stomach, lung, and pancreas. CASE REPORT: Here we report a rare case of HAC arising from the heterotopic pancreas (Heinrich type II) in the ileum with lymph node metastasis. A 56-year-old man was admitted to our hospital presenting with bloody stools under no obvious predisposing causes. The colonoscopy and the gastroscopy showed no pathological findings. A computed tomography scan showed an intussusception of ileum. Then partial resection of ileum was performed with end-to-end anastomosis and appendectomy. Histopathological examination showed a malignant transformation of heterotopic pancreas (Heinrich type II) in the ileum. We made the diagnosis of HAC based on clinical pathological features and immunochemical staining. The patient received chemotherapy and died 9 months later. CONCLUSION: To our best knowledge, this is the first reported case of HAC originated from a heterotopic pancreas in the ileum. The clinical pathological features and immunochemical staining are important for correct diagnosis of HAC. Wolters Kluwer Health 2016-08-19 /pmc/articles/PMC5370778/ /pubmed/27537551 http://dx.doi.org/10.1097/MD.0000000000004067 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Tong, Ling
Pan, Huaxiong
He, Jun
Weng, Mixia
Zheng, Liduan
Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title_full Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title_fullStr Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title_full_unstemmed Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title_short Hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: A case report
title_sort hepatoid adenocarcinoma arising from heterotopic pancreas of the ileum: a case report
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370778/
https://www.ncbi.nlm.nih.gov/pubmed/27537551
http://dx.doi.org/10.1097/MD.0000000000004067
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