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Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial

BACKGROUND: Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis...

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Autores principales: Ghazali, Wan Syaheedah Wan, Romli, Aminah Che, Mohamed, Mahaneem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371194/
https://www.ncbi.nlm.nih.gov/pubmed/28351393
http://dx.doi.org/10.1186/s12906-017-1703-6
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author Ghazali, Wan Syaheedah Wan
Romli, Aminah Che
Mohamed, Mahaneem
author_facet Ghazali, Wan Syaheedah Wan
Romli, Aminah Che
Mohamed, Mahaneem
author_sort Ghazali, Wan Syaheedah Wan
collection PubMed
description BACKGROUND: Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α among chronic smokers. METHODS/DESIGN: A total of 32 non-smokers and 64 chronic smokers from Quit Smoking Clinic and Health Campus, Universiti Sains Malaysia participated in the study. Smokers were then randomized into 2 groups: smokers with honey group that received Malaysian Tualang honey (20 g/day daily for 12 weeks) and smokers without honey group. Blood was obtained from non-smokers and smokers at pre-intervention, and from smokers at post-intervention for measurement of the inflammatory markers. RESULTS: At pre-intervention, smokers had significantly higher high sensitive C-reactive protein than non-smokers. In smokers with honey group, tumor necrosis factor-α was significantly increased while high sensitive C-reactive protein was significantly reduced at post-intervention than at pre-intervention. CONCLUSION: This study suggests that honey supplementation has opposite effects on tumor necrosis factor-α and high sensitive C-reactive protein indicating the inconclusive effect of honey on inflammation among chronic smokers which needs further study on other inflammatory markers. TRIAL REGISTRATION: The Trial has been registered in the Australian New Zealand Clinical Trials Registry: ACTRN12615001236583. Registered 11 November 2015 (Retrospectively Registered).
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spelling pubmed-53711942017-03-30 Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial Ghazali, Wan Syaheedah Wan Romli, Aminah Che Mohamed, Mahaneem BMC Complement Altern Med Research Article BACKGROUND: Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α among chronic smokers. METHODS/DESIGN: A total of 32 non-smokers and 64 chronic smokers from Quit Smoking Clinic and Health Campus, Universiti Sains Malaysia participated in the study. Smokers were then randomized into 2 groups: smokers with honey group that received Malaysian Tualang honey (20 g/day daily for 12 weeks) and smokers without honey group. Blood was obtained from non-smokers and smokers at pre-intervention, and from smokers at post-intervention for measurement of the inflammatory markers. RESULTS: At pre-intervention, smokers had significantly higher high sensitive C-reactive protein than non-smokers. In smokers with honey group, tumor necrosis factor-α was significantly increased while high sensitive C-reactive protein was significantly reduced at post-intervention than at pre-intervention. CONCLUSION: This study suggests that honey supplementation has opposite effects on tumor necrosis factor-α and high sensitive C-reactive protein indicating the inconclusive effect of honey on inflammation among chronic smokers which needs further study on other inflammatory markers. TRIAL REGISTRATION: The Trial has been registered in the Australian New Zealand Clinical Trials Registry: ACTRN12615001236583. Registered 11 November 2015 (Retrospectively Registered). BioMed Central 2017-03-28 /pmc/articles/PMC5371194/ /pubmed/28351393 http://dx.doi.org/10.1186/s12906-017-1703-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ghazali, Wan Syaheedah Wan
Romli, Aminah Che
Mohamed, Mahaneem
Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title_full Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title_fullStr Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title_full_unstemmed Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title_short Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
title_sort effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371194/
https://www.ncbi.nlm.nih.gov/pubmed/28351393
http://dx.doi.org/10.1186/s12906-017-1703-6
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