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Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells

Tetraarsenic hexoxide (As(4)O(6)) has been used in Korean folk medicines for the treatment of cancer, however its anti-cancer mechanisms remain obscured. Here, this study investigated the anti-cancer effect of As(4)O(6) on SW620 human colon cancer cells. As(4)O(6) has showed a dose-dependent inhibit...

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Detalles Bibliográficos
Autores principales:	Nagappan, Arulkumar, Lee, Won Sup, Yun, Jeong Won, Lu, Jing Nan, Chang, Seong-Hwan, Jeong, Jae-Hoon, Kim, Gon Sup, Jung, Jin-Myung, Hong, Soon Chan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371332/ https://www.ncbi.nlm.nih.gov/pubmed/28355296 http://dx.doi.org/10.1371/journal.pone.0174591

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