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Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent
Although the number of laparoscopic liver resections (LRRs) has increased, studies of surgical outcomes in comparison with the conventional open approach are limited. The purpose of this study was to analyze the surgical outcomes (safety and efficacy) of LLR versus open liver resection (OLR) for hep...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371500/ https://www.ncbi.nlm.nih.gov/pubmed/28328863 http://dx.doi.org/10.1097/MD.0000000000006460 |
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author | Chen, Junhua Li, Hongyu Liu, Fei Li, Bo Wei, Yonggang |
author_facet | Chen, Junhua Li, Hongyu Liu, Fei Li, Bo Wei, Yonggang |
author_sort | Chen, Junhua |
collection | PubMed |
description | Although the number of laparoscopic liver resections (LRRs) has increased, studies of surgical outcomes in comparison with the conventional open approach are limited. The purpose of this study was to analyze the surgical outcomes (safety and efficacy) of LLR versus open liver resection (OLR) for hepatocellular carcinoma (HCC). We collected data on all patients who received liver resection for HCC between April 2015 and September 2016 in our institution, and retrospectively investigated the demographic and perioperative data, and also surgical outcomes. Laparoscopic liver resection was performed in 225 patients and OLR in 291. In patients who underwent minor hepatectomy, LLR associated with a shorter duration of operation time (200 vs 220 minutes; P < 0.001), less blood loss (100 vs 225 mL; P < 0.001), lower transfusion rate (3.0% vs 12.0%; P = 0.012), and shorter postoperative hospital stay (6 vs 7 days; P < 0.001) compared with OLR. Dietary recovery was relatively fast in the group of LLR, but there were no significant differences in hepatic inflow occlusion rate, complication rate, and transfusion volume. Patients who received major hepatectomy had a longer duration of operation (240 vs 230 minutes; P < 0.001), less blood loss (200 vs 400 mL; P < 0.001), lower transfusion rate (4.8% vs 16.5%; P = 0.002), lower hepatic inflow occlusion rate (68.3% vs 91.7%; P < 0.001), and shorter postoperative hospital stay (6 vs 8 days; P < 0.001). Complication rate (P = 0.366) and transfusion volume (P = 0.308) did not differ between groups. Laparoscopic liver resection is a feasible and safe alternative to OLR for HCC when performed by a surgeon experienced with the relevant surgical techniques, associated with less blood loss, lower transfusion rate, a rapid return to a normal diet, and shorter postoperative hospital stay with no compromise in complications. Further, long-term follow-up should be acquired for adequate evaluation for survival. |
format | Online Article Text |
id | pubmed-5371500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-53715002017-04-03 Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent Chen, Junhua Li, Hongyu Liu, Fei Li, Bo Wei, Yonggang Medicine (Baltimore) 4500 Although the number of laparoscopic liver resections (LRRs) has increased, studies of surgical outcomes in comparison with the conventional open approach are limited. The purpose of this study was to analyze the surgical outcomes (safety and efficacy) of LLR versus open liver resection (OLR) for hepatocellular carcinoma (HCC). We collected data on all patients who received liver resection for HCC between April 2015 and September 2016 in our institution, and retrospectively investigated the demographic and perioperative data, and also surgical outcomes. Laparoscopic liver resection was performed in 225 patients and OLR in 291. In patients who underwent minor hepatectomy, LLR associated with a shorter duration of operation time (200 vs 220 minutes; P < 0.001), less blood loss (100 vs 225 mL; P < 0.001), lower transfusion rate (3.0% vs 12.0%; P = 0.012), and shorter postoperative hospital stay (6 vs 7 days; P < 0.001) compared with OLR. Dietary recovery was relatively fast in the group of LLR, but there were no significant differences in hepatic inflow occlusion rate, complication rate, and transfusion volume. Patients who received major hepatectomy had a longer duration of operation (240 vs 230 minutes; P < 0.001), less blood loss (200 vs 400 mL; P < 0.001), lower transfusion rate (4.8% vs 16.5%; P = 0.002), lower hepatic inflow occlusion rate (68.3% vs 91.7%; P < 0.001), and shorter postoperative hospital stay (6 vs 8 days; P < 0.001). Complication rate (P = 0.366) and transfusion volume (P = 0.308) did not differ between groups. Laparoscopic liver resection is a feasible and safe alternative to OLR for HCC when performed by a surgeon experienced with the relevant surgical techniques, associated with less blood loss, lower transfusion rate, a rapid return to a normal diet, and shorter postoperative hospital stay with no compromise in complications. Further, long-term follow-up should be acquired for adequate evaluation for survival. Wolters Kluwer Health 2017-03-24 /pmc/articles/PMC5371500/ /pubmed/28328863 http://dx.doi.org/10.1097/MD.0000000000006460 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 4500 Chen, Junhua Li, Hongyu Liu, Fei Li, Bo Wei, Yonggang Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title | Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title_full | Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title_fullStr | Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title_full_unstemmed | Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title_short | Surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
title_sort | surgical outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma for various resection extent |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371500/ https://www.ncbi.nlm.nih.gov/pubmed/28328863 http://dx.doi.org/10.1097/MD.0000000000006460 |
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