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Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function
Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological diff...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371610/ https://www.ncbi.nlm.nih.gov/pubmed/28424655 http://dx.doi.org/10.3389/fneur.2017.00117 |
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author | Curthoys, Ian S. MacDougall, Hamish G. Vidal, Pierre-Paul de Waele, Catherine |
author_facet | Curthoys, Ian S. MacDougall, Hamish G. Vidal, Pierre-Paul de Waele, Catherine |
author_sort | Curthoys, Ian S. |
collection | PubMed |
description | Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological differentiation. A specialized band of receptors called the striola consists of mainly type I receptors whose hair bundles are weakly tethered to the overlying otolithic membrane. The afferent neurons, which form calyx synapses on type I striolar receptors, have irregular resting discharge and have low thresholds to high frequency (e.g., 500 Hz) bone-conducted vibration and air-conducted sound. High-frequency sound and vibration likely causes fluid displacement which deflects the weakly tethered hair bundles of the very fast type I receptors. Irregular vestibular afferents show phase locking, similar to cochlear afferents, up to stimulus frequencies of kilohertz. We term these irregular afferents the transient system signaling dynamic otolithic stimulation. A 500-Hz vibration preferentially activates the otolith irregular afferents, since regular afferents are not activated at intensities used in clinical testing, whereas irregular afferents have low thresholds. We show how this sustained and transient distinction applies at the vestibular nuclei. The two systems have differential responses to vibration and sound, to ototoxic antibiotics, to galvanic stimulation, and to natural linear acceleration, and such differential sensitivity allows probing of the two systems. A 500-Hz vibration that selectively activates irregular otolithic afferents results in stimulus-locked eye movements in animals and humans. The preparatory myogenic potentials for these eye movements are measured in the new clinical test of otolith function—ocular vestibular-evoked myogenic potentials. We suggest 500-Hz vibration may identify the contribution of the transient system to vestibular controlled responses, such as vestibulo-ocular, vestibulo-spinal, and vestibulo-sympathetic responses. The prospect of particular treatments targeting one or the other of the transient or sustained systems is now being realized in the clinic by the use of intratympanic gentamicin which preferentially attacks type I receptors. We suggest that it is valuable to view vestibular responses by this sustained-transient distinction. |
format | Online Article Text |
id | pubmed-5371610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53716102017-04-19 Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function Curthoys, Ian S. MacDougall, Hamish G. Vidal, Pierre-Paul de Waele, Catherine Front Neurol Neuroscience Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological differentiation. A specialized band of receptors called the striola consists of mainly type I receptors whose hair bundles are weakly tethered to the overlying otolithic membrane. The afferent neurons, which form calyx synapses on type I striolar receptors, have irregular resting discharge and have low thresholds to high frequency (e.g., 500 Hz) bone-conducted vibration and air-conducted sound. High-frequency sound and vibration likely causes fluid displacement which deflects the weakly tethered hair bundles of the very fast type I receptors. Irregular vestibular afferents show phase locking, similar to cochlear afferents, up to stimulus frequencies of kilohertz. We term these irregular afferents the transient system signaling dynamic otolithic stimulation. A 500-Hz vibration preferentially activates the otolith irregular afferents, since regular afferents are not activated at intensities used in clinical testing, whereas irregular afferents have low thresholds. We show how this sustained and transient distinction applies at the vestibular nuclei. The two systems have differential responses to vibration and sound, to ototoxic antibiotics, to galvanic stimulation, and to natural linear acceleration, and such differential sensitivity allows probing of the two systems. A 500-Hz vibration that selectively activates irregular otolithic afferents results in stimulus-locked eye movements in animals and humans. The preparatory myogenic potentials for these eye movements are measured in the new clinical test of otolith function—ocular vestibular-evoked myogenic potentials. We suggest 500-Hz vibration may identify the contribution of the transient system to vestibular controlled responses, such as vestibulo-ocular, vestibulo-spinal, and vestibulo-sympathetic responses. The prospect of particular treatments targeting one or the other of the transient or sustained systems is now being realized in the clinic by the use of intratympanic gentamicin which preferentially attacks type I receptors. We suggest that it is valuable to view vestibular responses by this sustained-transient distinction. Frontiers Media S.A. 2017-03-30 /pmc/articles/PMC5371610/ /pubmed/28424655 http://dx.doi.org/10.3389/fneur.2017.00117 Text en Copyright © 2017 Curthoys, MacDougall, Vidal and de Waele. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Curthoys, Ian S. MacDougall, Hamish G. Vidal, Pierre-Paul de Waele, Catherine Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title | Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title_full | Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title_fullStr | Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title_full_unstemmed | Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title_short | Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function |
title_sort | sustained and transient vestibular systems: a physiological basis for interpreting vestibular function |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371610/ https://www.ncbi.nlm.nih.gov/pubmed/28424655 http://dx.doi.org/10.3389/fneur.2017.00117 |
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