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The influence of Sm-153 therapy on bone marrow function
AIM OF THE STUDY: Studies about possible risks connected with β-emitterradiotherapy concentrate mainly on potential myelotoxicity. Results of previously published analysis based on white blood cells (WBC) and platelet (PLT) counts – before and after radionuclide treatment – are quite varied. The aim...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371705/ https://www.ncbi.nlm.nih.gov/pubmed/28373820 http://dx.doi.org/10.5114/wo.2016.64598 |
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author | Małkowski, Bogdan Maruszak, Marta Dudek, Anna Wędrowski, Mateusz Szefer, Jarosław |
author_facet | Małkowski, Bogdan Maruszak, Marta Dudek, Anna Wędrowski, Mateusz Szefer, Jarosław |
author_sort | Małkowski, Bogdan |
collection | PubMed |
description | AIM OF THE STUDY: Studies about possible risks connected with β-emitterradiotherapy concentrate mainly on potential myelotoxicity. Results of previously published analysis based on white blood cells (WBC) and platelet (PLT) counts – before and after radionuclide treatment – are quite varied. The aim of our study was to present the greatest possible impact of Samarium-153 on bone marrow function in clinical practice. MATERIAL AND METHODS: The study included the blood test results of 175 patients with bone metastases treated with Sm-153 in the years 2012–2014. We compared levels of WBC, PLT, red blood cells (RBC), and haemoglobin (HGB) from two blood tests – one performed directly before the therapy and the other 2–6 weeks after isotope injection. RESULTS AND CONCLUSIONS: The study showed decreased mean level of WBC in a control test performed after therapy in comparison to output results at about 27.1%. In our study 1.1% of patients developed the third-grade toxicity in CTCAE (Common Terminology Criteria for Adverse Events). Mean decrease of PLT was about 18%. Three patients (1.7% of all) result qualified as third-grade toxicity in a control test, one as fourth-grade. Analysis of RBC level showed 5.7% reduction of output values. The same calculation was seen for HGB – 5.1%. The greatest but acceptable decrease in haematological parameters was observed in WBC and PLT. Analysis of changes in WBC and PLT level showed them to be similar or smaller than was proven in previously published studies. |
format | Online Article Text |
id | pubmed-5371705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-53717052017-04-03 The influence of Sm-153 therapy on bone marrow function Małkowski, Bogdan Maruszak, Marta Dudek, Anna Wędrowski, Mateusz Szefer, Jarosław Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: Studies about possible risks connected with β-emitterradiotherapy concentrate mainly on potential myelotoxicity. Results of previously published analysis based on white blood cells (WBC) and platelet (PLT) counts – before and after radionuclide treatment – are quite varied. The aim of our study was to present the greatest possible impact of Samarium-153 on bone marrow function in clinical practice. MATERIAL AND METHODS: The study included the blood test results of 175 patients with bone metastases treated with Sm-153 in the years 2012–2014. We compared levels of WBC, PLT, red blood cells (RBC), and haemoglobin (HGB) from two blood tests – one performed directly before the therapy and the other 2–6 weeks after isotope injection. RESULTS AND CONCLUSIONS: The study showed decreased mean level of WBC in a control test performed after therapy in comparison to output results at about 27.1%. In our study 1.1% of patients developed the third-grade toxicity in CTCAE (Common Terminology Criteria for Adverse Events). Mean decrease of PLT was about 18%. Three patients (1.7% of all) result qualified as third-grade toxicity in a control test, one as fourth-grade. Analysis of RBC level showed 5.7% reduction of output values. The same calculation was seen for HGB – 5.1%. The greatest but acceptable decrease in haematological parameters was observed in WBC and PLT. Analysis of changes in WBC and PLT level showed them to be similar or smaller than was proven in previously published studies. Termedia Publishing House 2016-12-20 2016 /pmc/articles/PMC5371705/ /pubmed/28373820 http://dx.doi.org/10.5114/wo.2016.64598 Text en Copyright: © 2016 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Małkowski, Bogdan Maruszak, Marta Dudek, Anna Wędrowski, Mateusz Szefer, Jarosław The influence of Sm-153 therapy on bone marrow function |
title | The influence of Sm-153 therapy on bone marrow function |
title_full | The influence of Sm-153 therapy on bone marrow function |
title_fullStr | The influence of Sm-153 therapy on bone marrow function |
title_full_unstemmed | The influence of Sm-153 therapy on bone marrow function |
title_short | The influence of Sm-153 therapy on bone marrow function |
title_sort | influence of sm-153 therapy on bone marrow function |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371705/ https://www.ncbi.nlm.nih.gov/pubmed/28373820 http://dx.doi.org/10.5114/wo.2016.64598 |
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